methyl (S)-2-acetamido-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

Base Information

• Chemical Name: methyl (S)-2-acetamido-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate
• CAS No.: 107658-26-4
• Molecular Formula: C₁₃H₁₄F₃NO₆S
• Molecular Weight: 369.318
• Mol file: 107658-26-4.mol

Synonyms:methyl (S)-2-acetamido-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

Chemical Property of methyl (S)-2-acetamido-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl (S)-2-acetamido-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

There total 5 articles about methyl (S)-2-acetamido-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + N-acetyl-L-tyrosine methyl ester (2440-79-1) → methyl (S)-2-acetamido-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate (107658-26-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine;

DOI:10.1021/jo960077z

Reference yield: 89.0%

para-nitrophenyl triflate (17763-80-3) + N-acetyl-L-tyrosine methyl ester (2440-79-1) → methyl (S)-2-acetamido-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate (107658-26-4)

Guidance literature:

With 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL; In acetonitrile; at 80 ℃;

DOI:10.1016/S0040-4039(99)01529-4

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + N-acetyl-L-tyrosine methyl ester (2440-79-1) → methyl (S)-2-acetamido-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate (107658-26-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 1h; Schlenk technique;

DOI:10.1002/anie.201905971

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

N-acetyl-L-tyrosine methyl ester

para-nitrophenyl triflate

trifluoromethylsulfonic anhydride

Downstream raw materials:

N-acetyl-p-(diphenylphosphino)-L-phenylalanine metyl ester