1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid(4-chlorobenzyl)methylamide

Base Information

Chemical Name:1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid(4-chlorobenzyl)methylamide
CAS No.:1391073-35-0
Molecular Formula:C₂₃H₂₇ClN₂O₂
Molecular Weight:398.933
Hs Code.:

Synonyms:1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid(4-chlorobenzyl)methylamide

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Chemical Property of 1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid(4-chlorobenzyl)methylamide

Chemical Property:

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Technology Process of 1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid(4-chlorobenzyl)methylamide

There total 7 articles about 1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid(4-chlorobenzyl)methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 42288-46-0
(3,5-dimethylphenyl)acetic acid

: C₁₃H₁₇ClN₂O*ClH

: 1391073-35-0
1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid(4-chlorobenzyl)methylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jm5012885

Reference yield:

: 2-[(4-chlorobenzyl)methylcarbamoyl]-2-methylazetidine-1-carboxylic acid tert-butyl ester

: 1391073-35-0
1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid(4-chlorobenzyl)methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 15 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5012885

Reference yield:

: 449758-77-4,1198339-37-5
1-(tert-butoxycarbonyl)-2-methylazetidine-2-carboxylic acid

: 1391073-35-0
1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carboxylic acid(4-chlorobenzyl)methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / dichloromethane / 15 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 15 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5012885