Technology Process of 2-(3-aminophenylethynyl)benzoic acid methyl ester
There total 5 articles about 2-(3-aminophenylethynyl)benzoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-Iodoaniline;
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
2-ethynyl-benzoic acid methyl ester;
at 0 ℃;
for 9h;
DOI:10.1016/j.molstruc.2017.02.096
- Guidance literature:
-
3-Iodoaniline; methyl 2-(2-trimethylsilyl-1-ethynyl)benzoate;
With
piperidine; trans-bis(triphenylphosphine)palladium dichloride; triphenylphosphine;
In
tetrahydrofuran;
for 0.333333h;
Inert atmosphere;
With
copper(l) iodide; potassium carbonate;
In
tetrahydrofuran; methanol;
for 18h;
Inert atmosphere;
Reflux;
DOI:10.1021/jo202604q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine / tetrahydrofuran / 0.33 h / Inert atmosphere
1.2: 18 h / 20 °C / Inert atmosphere
2.1: piperidine; trans-bis(triphenylphosphine)palladium dichloride; triphenylphosphine / tetrahydrofuran / 0.33 h / Inert atmosphere
2.2: 18 h / Inert atmosphere; Reflux
With
piperidine; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine;
In
tetrahydrofuran;
1.1: Sonogashira coupling / 1.2: Sonogashira coupling / 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1021/jo202604q
