2-(4-bromophenyl)propanal

Base Information

• Chemical Name: 2-(4-bromophenyl)propanal
• CAS No.: 40460-91-1
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.074
• Mol file: 40460-91-1.mol

Synonyms:2-(4-bromophenyl)propanal

Chemical Property of 2-(4-bromophenyl)propanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-bromophenyl)propanal

There total 21 articles about 2-(4-bromophenyl)propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-bromo-α-methylstyrene oxide (80909-78-0) → 2-(4-bromophenyl)propanal (40460-91-1)

Guidance literature:

With C₃₆H₅₄IrNP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); In tetrahydrofuran; at 23 - 100 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c4cc05260a

Reference yield: 95.0%

1-bromo-4-ethenyl-benzene (2039-82-9) + carbon monoxide (201230-82-2) → 2-(4-bromophenyl)propanal (40460-91-1) + 3-(4-bromophenyl)propanal (80793-25-5)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; sodium 4-dodecylbenzenesulfonate; Sodium; 2-[bis-(2-diphenylphosphanyl-ethyl)-carbamoyl]-benzenesulfonate; In water; toluene; at 60 ℃; under 30003 Torr;

DOI:10.1016/j.cclet.2021.07.068

Reference yield: 80.0%

1-bromo-4-(1-methoxyprop-1-en-2-yl)-benzene → 2-(4-bromophenyl)propanal (40460-91-1)

Guidance literature:

With hydrogen bromide; In water; acetone; at 0 - 23 ℃; for 46h;

DOI:10.1021/acs.orglett.5b01193

upstream raw materials:

3-(4-Bromo-phenyl)-3-methyl-oxirane-2-carbonitrile

t-butyl β-methyl-β-(p-bromophenyl)glycidate

methylmagnesium bromide

para-bromophenacyl bromide

Refernces

• 1、 Manetti, Dina,Romanelli, Maria Novella,Bartolini, Alessandro,Dei, Silvia,Ghelardini, Carla,Gualtieri, Fulvio,Matucci, Rosanna,Scapecchi, Serena,Teodori, Elisabetta. "Reduced flexibility analogs of analgesic and cognition enhancing α-tropanyl esters". . p. 105 - 111. Retrieved 1996.
• 2、 Li, Tingting,Hammond, Gerald B.,Xu, Bo. "Cobalt-Catalyzed Aerobic Oxidative Cleavage of Alkyl Aldehydes: Synthesis of Ketones, Esters, Amides, and α-Ketoamides". supporting information. p. 9737 - 9741. Retrieved 2021/05/31.
• 3、 Zhang, Yang,Torker, Sebastian,Sigrist, Michel,Bregovi?, Nikola,Dydio, Pawe?. "Binuclear Pd(I)-Pd(I) Catalysis Assisted by Iodide Ligands for Selective Hydroformylation of Alkenes and Alkynes". supporting information. p. 18251 - 18265. Retrieved 2020/11/02.