(3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-ethylenedipyrrolidine

Base Information

Chemical Name:(3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-ethylenedipyrrolidine
CAS No.:109297-17-8
Molecular Formula:C₄₂H₅₂N₂
Molecular Weight:584.888
Hs Code.:

Synonyms:(3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-ethylenedipyrrolidine

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Chemical Property of (3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-ethylenedipyrrolidine

Chemical Property:

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Technology Process of (3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-ethylenedipyrrolidine

There total 12 articles about (3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-ethylenedipyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 154808-96-5
(3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-oxalyldipyrrolidine

: 109297-17-8
(3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-ethylenedipyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1016/S0040-4020(01)80176-9

Reference yield:

: 109297-19-0
trans-2,3-bis(3,5-dimethylphenyl)succinic anhydride

: 109297-17-8
(3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-ethylenedipyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 48 percent / benzene / 5 h / Ambient temperature

2: 68 percent / conc. HCl, acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 1 h / Heating

4: 76 percent / formic acid / Pd-C (10percent) / methanol / 48 h

5: 77 percent / Et₃N / CH₂Cl₂ / 0.17 h / Ambient temperature

6: 84 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; formic acid; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)80176-9

Reference yield:

: 5779-95-3
3,5-dimethylbenzaldehyde

: 109297-17-8
(3R,3'R,4R,4'R)-3,3',4,4'-tetrakis(3,5-dimethylphenyl)-1,1'-ethylenedipyrrolidine

Guidance literature:: Multi-step reaction with 9 steps

1: 50 percent / NaCN / H₂O; methanol / 15 h / Heating

2: 60 percent / 98percent H₂SO₄ / ethanol / 48 h / Heating

3: 78 percent / acetyl chloride / 12 h / Ambient temperature

4: 48 percent / benzene / 5 h / Ambient temperature

5: 68 percent / conc. HCl, acetic acid / 24 h / Heating

6: LiAlH₄ / tetrahydrofuran / 1 h / Heating

7: 76 percent / formic acid / Pd-C (10percent) / methanol / 48 h

8: 77 percent / Et₃N / CH₂Cl₂ / 0.17 h / Ambient temperature

9: 84 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; formic acid; sulfuric acid; sodium cyanide; acetic acid; triethylamine; acetyl chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; benzene;
DOI:10.1016/S0040-4020(01)80176-9