2-Bromo-4-chlorophenylboronic acid

Base Information

• Chemical Name: 2-Bromo-4-chlorophenylboronic acid
• CAS No.: 1451393-45-5
• Molecular Formula: C₆H₅BBrClO₂
• Molecular Weight: 235.272
• Mol file: 1451393-45-5.mol

Synonyms:(2-bromo-4-chlorophenyl)boronic acid

Chemical Property of 2-Bromo-4-chlorophenylboronic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(2-Bromo-4-chlorophenyl)boronicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Bromo-4-chlorophenylboronic acid

There total 3 articles about 2-Bromo-4-chlorophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-bromo-4-chloroiodobenzene (31928-44-6) + Trimethyl borate (121-43-7,63156-11-6) → (2-bromo-4-chlorophenyl)boronic acid (1451393-45-5)

Guidance literature:

2-bromo-4-chloroiodobenzene; With isopropylmagnesium bromide; In tetrahydrofuran; at -78 ℃; for 1h;

Trimethyl borate; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1002/anie.201708892

Reference yield:

2-bromo-4-chloroiodobenzene (31928-44-6) + triethyl borate (150-46-9) → (2-bromo-4-chlorophenyl)boronic acid (1451393-45-5)

Guidance literature:

2-bromo-4-chloroiodobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 2h;

triethyl borate; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water; at 20 ℃; for 0.5h;

DOI:10.1021/ol5006246

Reference yield:

2-bromo-4-chloroiodobenzene (31928-44-6) + Triisopropyl borate (5419-55-6) → (2-bromo-4-chlorophenyl)boronic acid (1451393-45-5)

Guidance literature:

2-bromo-4-chloroiodobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 2h; Inert atmosphere; Schlenk technique;

Triisopropyl borate; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Inert atmosphere; Schlenk technique;

With hydrogenchloride; water; at 20 ℃; for 0.5h;

DOI:10.1021/jacs.1c01339

upstream raw materials:

2-bromo-4-chloroiodobenzene

triethyl borate

Trimethyl borate

Triisopropyl borate

Downstream raw materials:

2-(2-bromo-4-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane