diethyl [1,1-2H₂]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate

Base Information

Chemical Name:diethyl [1,1-2H₂]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate
CAS No.:389852-59-9
Molecular Formula:C₂₃H₃₅NO₇
Molecular Weight:439.518
Hs Code.:

diethyl [1,1-2H<sub>2</sub>]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate

Synonyms:diethyl [1,1-2H₂]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate

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Chemical Property of diethyl [1,1-2H₂]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate

Chemical Property:

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Technology Process of diethyl [1,1-2H₂]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate

There total 7 articles about diethyl [1,1-2H₂]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

: 102831-44-7
diethyl tert-butoxycarbonylaminomalonate

: 389852-58-8
[1,1-2H₂]-4-benzyloxy-1-bromobutane

: 389852-59-9
diethyl [1,1-2H₂]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate

Guidance literature:: diethyl tert-butoxycarbonylaminomalonate; With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h;

[1,1-2H₂]-4-benzyloxy-1-bromobutane; In ethanol; for 3h; Heating;
DOI:10.1246/bcsj.74.2199

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 389852-59-9
diethyl [1,1-2H₂]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Jones reagent / acetone / 0.5 h

2.1: 2.56 g / aq. H₂SO₄ / 3 h / Heating

3.1: 72.5 percent / LiAl⁽²⁾H₄ / tetrahydrofuran / 1 h

4.1: 97.3 percent / PPh₃; CBr₄ / CH₂Cl₂ / 3 h / 20 °C

5.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

5.2: 83.2 percent / ethanol / 3 h / Heating

With jones reagent; lithium aluminium deuteride; carbon tetrabromide; sulfuric acid; sodium ethanolate; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; acetone; 1.1: Jones oxidation;
DOI:10.1246/bcsj.74.2199

Reference yield:

: 2749-68-0
2-phenyl-[1,3]dioxepane

: 389852-59-9
diethyl [1,1-2H₂]-4-benzyloxybutyl-N-t-butoxycarbonylaminomalonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 12.0 g / LiAlH₄; AlCl₃ / CH₂Cl₂; diethyl ether / 2 h / Heating

2.1: Jones reagent / acetone / 0.5 h

3.1: 2.56 g / aq. H₂SO₄ / 3 h / Heating

4.1: 72.5 percent / LiAl⁽²⁾H₄ / tetrahydrofuran / 1 h

5.1: 97.3 percent / PPh₃; CBr₄ / CH₂Cl₂ / 3 h / 20 °C

6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

6.2: 83.2 percent / ethanol / 3 h / Heating

With lithium aluminium tetrahydride; aluminium trichloride; jones reagent; lithium aluminium deuteride; carbon tetrabromide; sulfuric acid; sodium ethanolate; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone; 2.1: Jones oxidation;
DOI:10.1246/bcsj.74.2199