[18F]4'-fluorobenzyl iodide

Base Information

• Chemical Name: [18F]4'-fluorobenzyl iodide
• CAS No.: 134430-72-1
• Molecular Formula: C₇H₆FI
• Molecular Weight: 235.029
• Mol file: 134430-72-1.mol

Synonyms:[18F]4'-fluorobenzyl iodide

Chemical Property of [18F]4'-fluorobenzyl iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of [18F]4'-fluorobenzyl iodide

There total 4 articles about [18F]4'-fluorobenzyl iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[18F]fluorofluorobenzyl alcohol (659-46-1) → [18F]4'-fluorobenzyl iodide (134430-72-1)

Guidance literature:

With hydrogen iodide; at 90 ℃;

DOI:10.1002/jlcr.2580360302

Reference yield:

4-[18F]fluorobenzaldehyde (115109-21-2) → [18F]4'-fluorobenzyl iodide (134430-72-1)

Guidance literature:

With lithium aluminium tetrahydride; hydrogen iodide; Multistep reaction; 1.) THF, pentane;

DOI:10.1021/jm00075a028

Reference yield:

4-trimethylammoniumbenzaldehyde triflate → [18F]4'-fluorobenzyl iodide (134430-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride / water; dimethyl sulfoxide / 0.04 h / 140 °C

2: sodium tetrahydroborate / water / 0.03 h / Solid phase extraction cartridge

3: hydrogen iodide / water / 0.03 h / 60 °C / Solid phase extraction cartridge

With sodium tetrahydroborate; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; hydrogen iodide; In water; dimethyl sulfoxide;

DOI:10.1016/j.jfluchem.2012.03.015

upstream raw materials:

4-[18F]fluorobenzaldehyde

4-[18F]fluorofluorobenzyl alcohol

4-nitrobenzaldehdye

Downstream raw materials:

2-fluorobenzyl azide

(+)-[18F]fluorobenzyltrozamicol