659-46-1

Upstream product

• 115109-21-2 4-[18F]fluorobenzaldehyde 
• 134430-70-9 p-[18F]fluorobenzyl bromide 
• 46061-36-3 trimethylammonium-4-benzaldehyde 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 321195-46-4 6-(4-[⁽¹⁸⁾F]fluoro-benzyloxy)-9H-purin-2-ylamine 
• 1376770-05-6 C₇H₆Cl⁽¹⁸⁾F 
• 62284-30-4 2-fluorobenzyl azide 
• 134430-70-9 p-[18F]fluorobenzyl bromide 
• 134430-72-1 [18F]4'-fluorobenzyl iodide 

Relevant academic research and scientific papers

Radiosynthesis and preliminary biological evaluation of a new 18F-labeled triethylene glycol derivative of triphenylphosphonium

Delocalized lipophilic cations such as [18F]fluorobenzyltriphenylphosphonium ([18F]FBnTP) can accumulate in mitochondria and have been used in myocardial perfusion imaging (MPI). In this study, we established a simplified method for

A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion

The 4-[18F]-fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [18F]-fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4-[18F]-fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/μmole at end of synthesis.

Fast and reliable method for the preparation of ortho- and para-[ 18F]fluorobenzyl halide derivatives: Key intermediates for the preparation of no-carrier-added PET aromatic radiopharmaceuticals

A fast and reliable method suitable for the automated preparation of (substituted) [18F]fluorobenzyl halides from several [ 18F]fluorobenzaldehydes was developed. Aromatic nucleophilic substitution of trimethylammonium benzaldehyde t

COMPOSITIONS, METHODS, AND KITS FOR DETERMINING AN ALKYL TRANSFERASE

The present invention relates to novel compounds as well as to compositions, methods, and kits comprising the compounds for determining an alkyltransferase (ATase), in particular an alkylguanine-DNA alkyl transferase (AGT). In general, the novel compounds

Radiolabeling of a high potency cannabinoid subtype-1 receptor ligand, N-(4-fluoro-benzyl)-4-(3-(piperidin-1-yl)-indole-1-sulfonyl) benzamide (PipISB), with carbon-11 or fluorine-18

PipISB [N-(4-fluoro-benzyl)-4-(3-(piperidin-1-yl)-indole-1-sulfonyl) benzamide, 9] was identified as a selective high potency CB1 receptor ligand. Here we describe the labeling of 9 with positron-emitters to provide candidate radioligands for i

N1'-(p-[18F]fluorobenzyl)naltrindole (p-[18F]BNTI) as a potential PET imaging agent for DOP receptors

The N1'-(p-fluorobenzyl)naltrindole 5 has been synthesized by reaction of 3-O-benzyl NTI 3 with p-fluorobenzylbromide under phase transfer catalysis. The subsequent 3-O-benzyldeprotection of 4 in HBr/CH3COOH gave the target compound 5 in three

Radiosynthesis of 3-[18F]fluoropropyl and 4-[ 18F]fluorobenzyl triarylphosphonium ions

3-[18F]Fluoropropyl-, 4-[18F]fluorobenzyl- triphenylphosphonium and 4-[18F]fluorobenzyltris-4- dimethylaminophenylphosphonium cations were synthesized in multistep reactions from no carrier added (nca) [18F]fluo

Synthesis of 3-[1H-imidazol-4-yl] propyl 4-[18F] fluorobenzyl ether ([18F] fluoroproxyfan): A potential radioligand for imaging histamine H3 receptors

3-[1H-Imidazol-4-yl]propyl 4-fluorobenzyl ether (fluoroproxyfan), a potential histamine H3 receptor ligand, was labeled with 18F for clinical PET studies. The synthesis involved the O-alkylation of 3-(1 -triphenylmethyl-1H-imidazol-4