2-{4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:2-{4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:1533426-10-6
Molecular Formula:C₂₉H₃₁FN₂O₂
Molecular Weight:458.576
Hs Code.:

Synonyms:2-{4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 2-{4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 2-{4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 2-{4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 163630-97-5
4-<1-(4-fluorophenyl)-1H-indol-3-yl>-1-butanol methanesulfonate ester

: 1533426-10-6
2-{4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.333333h;
DOI:10.1002/cmdc.201300291

Reference yield: 44.0%

: C₁₈H₁₇BrFN

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 1533426-10-6
2-{4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With potassium carbonate; In acetonitrile; Reflux;
DOI:10.1039/c5md00079c

Reference yield:

: 133-32-4
4-indol-3-yl-butyric acid

: 1533426-10-6
2-{4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; potassium carbonate / 2-ethoxy-ethanol / 0.67 h / 200 °C / Microwave irradiation

2: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1 h / 0 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 100 °C

With copper(l) iodide; lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300291