methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

Base Information

Chemical Name:methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate
CAS No.:89578-74-5
Molecular Formula:C₃₁H₅₄N₂O₅SSi
Molecular Weight:594.932
Hs Code.:

methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

Synonyms:methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

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Chemical Property of methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

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Technology Process of methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

There total 16 articles about methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 89578-70-1
methyl (2α,6β)-1,2,3,6-tetrahydro-6(S*)-<2-(tert-butyldimethylsiloxy)heptyl>-2-pyridineacetate

: 264218-69-1
trifluoromethanesulfonic acid 3-(toluene-4-sulfonylamino)propyl ester

: 89578-74-5
methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/ja00323a030

Reference yield:

: 13379-98-1
3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

: 89578-74-5
methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C

2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja00323a030

Reference yield:

: 72952-73-9
(E)-2,4-pentadienyltrimethylsilane

: 89578-74-5
methyl <2α,6β(S*)>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

Guidance literature:: Multi-step reaction with 13 steps

1: 69 percent / TiCl₄ / CH₂Cl₂ / -41 °C

2: 95 percent / trifluoroacetic acid / 24 h

3: 82 percent / acetone / 72 h / Heating

4: 97 percent / pyridine / 12 h

5: 83 percent / diisopropyl-ethylamine / toluene / 3 h / 215 °C

6: 96 percent / 5percent NaOH / methanol / 2 h / Ambient temperature

7: oxalyl chloride / toluene / 3 h / Ambient temperature

8: diethyl ether / 1 h / Ambient temperature

9: Ag₂O / 12 h

10: Ba(OH)2*8H₂O / various solvent(s); H₂O / 48 h / Heating

11: SOCl₂ / 12 h / Heating

12: 91 percent / 2,6-lutidine / CH₂Cl₂ / 4 h / 0 °C

13: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

With 2,6-dimethylpyridine; barium dihydroxide; sodium hydroxide; thionyl chloride; oxalyl dichloride; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In pyridine; methanol; diethyl ether; dichloromethane; water; acetone; toluene; trifluoroacetic acid;
DOI:10.1021/ja00323a030