5-chloro-2-diphenylthiophosphinyl-2-methylpentanonitrile

Base Information

Chemical Name:5-chloro-2-diphenylthiophosphinyl-2-methylpentanonitrile
CAS No.:223473-53-8
Molecular Formula:C₁₈H₁₉ClNPS
Molecular Weight:347.848
Hs Code.:

Synonyms:5-chloro-2-diphenylthiophosphinyl-2-methylpentanonitrile

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Chemical Property of 5-chloro-2-diphenylthiophosphinyl-2-methylpentanonitrile

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Technology Process of 5-chloro-2-diphenylthiophosphinyl-2-methylpentanonitrile

There total 3 articles about 5-chloro-2-diphenylthiophosphinyl-2-methylpentanonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 109-70-6
1.3-chlorobromopropane

: 211635-58-4
(diphenylphosphinothioyl)methylacetonitrile

: 223473-53-8
5-chloro-2-diphenylthiophosphinyl-2-methylpentanonitrile

Guidance literature:: With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In acetonitrile; for 3h;

Reference yield:

: 69039-10-7
(diphenylthiophosphinoyl)acetonitrile

: 109-70-6
1.3-chlorobromopropane

: 223473-53-8
5-chloro-2-diphenylthiophosphinyl-2-methylpentanonitrile

Guidance literature:: (diphenylthiophosphinoyl)acetonitrile; MeX (X=halogen); With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; at 20 ℃; for 3h;

1.3-chlorobromopropane; With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In acetonitrile; at 20 ℃; for 3h;
DOI:10.1002/hc.1101

Reference yield:

: 69039-10-7
(diphenylthiophosphinoyl)acetonitrile

: 223473-53-8
5-chloro-2-diphenylthiophosphinyl-2-methylpentanonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent aq. NaOH / CH₂Cl₂

2: KOH; Et₃PhCH₂NCl / acetonitrile

With potassium hydroxide; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; acetonitrile; 1: Methylation / 2: Alkylation;
DOI:10.1080/10426509908546313