1-tert-butoxy-3-(tert-butyldiphenylsilyloxy)-1-oxopropan-2-yl pyrrolidine-1-carboxylate

Base Information

Chemical Name:1-tert-butoxy-3-(tert-butyldiphenylsilyloxy)-1-oxopropan-2-yl pyrrolidine-1-carboxylate
CAS No.:1041400-07-0
Molecular Formula:C₂₈H₃₉NO₅Si
Molecular Weight:497.707
Hs Code.:

Synonyms:1-tert-butoxy-3-(tert-butyldiphenylsilyloxy)-1-oxopropan-2-yl pyrrolidine-1-carboxylate

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Chemical Property of 1-tert-butoxy-3-(tert-butyldiphenylsilyloxy)-1-oxopropan-2-yl pyrrolidine-1-carboxylate

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Technology Process of 1-tert-butoxy-3-(tert-butyldiphenylsilyloxy)-1-oxopropan-2-yl pyrrolidine-1-carboxylate

There total 4 articles about 1-tert-butoxy-3-(tert-butyldiphenylsilyloxy)-1-oxopropan-2-yl pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1041400-23-0,1041399-97-6,1041400-08-1
(+/-)-3-(tert-butyldiphenylsilyloxy)-2-(pyrrolidine-1-carbonyloxy)propanoic acid

: 75-65-0
tert-butyl alcohol

: 1041400-07-0
1-tert-butoxy-3-(tert-butyldiphenylsilyloxy)-1-oxopropan-2-yl pyrrolidine-1-carboxylate

Guidance literature:: (+/-)-3-(tert-butyldiphenylsilyloxy)-2-(pyrrolidine-1-carbonyloxy)propanoic acid; With 2,4,6-trimethyl-pyridine; dicyclohexyl-carbodiimide; In tetrachloromethane; at -20 ℃; for 1h; Inert atmosphere;

tert-butyl alcohol; With Trimethylacetic acid; (S)-(+)-1-tert-butyldiphenylsilyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane; In tetrachloromethane; at -20 ℃; for 17h; Inert atmosphere;

With hydrogenchloride; water; In tetrachloromethane; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol801007m

Reference yield:

: C₂₉H₃₉NO₆Si

: 75-65-0
tert-butyl alcohol

: 1041400-23-0,1041399-97-6,1041400-08-1
(+/-)-3-(tert-butyldiphenylsilyloxy)-2-(pyrrolidine-1-carbonyloxy)propanoic acid

: 1041400-07-0
1-tert-butoxy-3-(tert-butyldiphenylsilyloxy)-1-oxopropan-2-yl pyrrolidine-1-carboxylate

Guidance literature:: C₂₉H₃₉NO₆Si; tert-butyl alcohol; With Trimethylacetic acid; (S)-(+)-1-tert-butyldiphenylsilyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane; In tetrachloromethane; at -20 ℃; for 52h; Inert atmosphere;

With hydrogenchloride; water; In tetrachloromethane; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol801007m

Reference yield:

: C₂₉H₃₉NO₆Si

: 75-65-0
tert-butyl alcohol

: (+)-3-(tert-butyldiphenylsilyloxy)-2-(pyrrolidine-1-carbonyloxy)propanoic acid

: (-)-3-(tert-butyldiphenylsilyloxy)-2-(pyrrolidine-1-carbonyloxy)propanoic acid

: 1041400-07-0
1-tert-butoxy-3-(tert-butyldiphenylsilyloxy)-1-oxopropan-2-yl pyrrolidine-1-carboxylate

Guidance literature:: C₂₉H₃₉NO₆Si; tert-butyl alcohol; With (S)-(-)-1-tris(trimethylsilyl)silyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-[3'',5''-bis(trifluoromethyl)benzenesulfonylamino]propane; Trimethylacetic acid; In tetrachloromethane; at -20 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; water; In tetrachloromethane; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol801007m