4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile

Base Information

• Chemical Name: 4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile
• CAS No.: 1441119-09-0
• Molecular Formula: C₁₇H₁₁N₅O₂
• Molecular Weight: 317.307
• Mol file: 1441119-09-0.mol

Synonyms:4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile

Chemical Property of 4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile

There total 2 articles about 4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-nitrobenzylidenemalononitrile (2826-32-6) + benzamidin (618-39-3) → 4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile (1441119-09-0)

Guidance literature:

With piperidine; In methanol; for 6h; Reflux;

DOI:10.1080/00397911.2016.1151051

Reference yield: 96.0%

benzamidine monohydrochloride (1670-14-0) + 3-nitro-benzaldehyde (99-61-6) + malononitrile (109-77-3) → 4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile (1441119-09-0)

Guidance literature:

With iron oxide; In neat (no solvent); at 100 ℃;

DOI:10.1016/j.cclet.2013.04.035

Reference yield: 91.0%

4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile (1441119-09-0) + benzenesulfonyl chloride (98-09-9) → 4-phenylsulfonamido-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile

Guidance literature:

4-amino-6-(3-nitrophenyl)-2-phenylpyrimidine-5-carbonitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

benzenesulfonyl chloride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1080/10426507.2015.1050017

upstream raw materials:

benzamidine monohydrochloride

3-nitro-benzaldehyde

malononitrile

3-nitrobenzylidenemalononitrile

Downstream raw materials:

4-(3-aminophenyl)-6-phenyl-1H-pyrazolo[3,4-d]pyrimidin-3-amine