9-[2'-O-benzoyl-3'-O-((2-cyanoethoxy)(diisopropylamino)phosphino)-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N²-isobutyrylguanine

Base Information

• Chemical Name: 9-[2'-O-benzoyl-3'-O-((2-cyanoethoxy)(diisopropylamino)phosphino)-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N²-isobutyrylguanine
• CAS No.: 253875-10-4
• Molecular Formula: C₅₁H₅₈N₇O₁₀P
• Molecular Weight: 960.036

Synonyms:9-[2'-O-benzoyl-3'-O-((2-cyanoethoxy)(diisopropylamino)phosphino)-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N²-isobutyrylguanine

Chemical Property of 9-[2'-O-benzoyl-3'-O-((2-cyanoethoxy)(diisopropylamino)phosphino)-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N²-isobutyrylguanine

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Technology Process of 9-[2'-O-benzoyl-3'-O-((2-cyanoethoxy)(diisopropylamino)phosphino)-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N²-isobutyrylguanine

There total 2 articles about 9-[2'-O-benzoyl-3'-O-((2-cyanoethoxy)(diisopropylamino)phosphino)-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N²-isobutyrylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 9-[2'-O-benzoyl-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N2-isobutyrguanine (389089-98-9) → 9-[2'-O-benzoyl-3'-O-((2-cyanoethoxy)(diisopropylamino)phosphino)-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N2-isobutyrylguanine (253875-10-4)

Guidance literature:

With 1-methyl-1H-imidazole; 2,4,6-trimethyl-pyridine; In dichloromethane; at 20 ℃;

DOI:10.1016/S0968-0896(01)00220-6

Reference yield:

benzoyl chloride (98-88-4) → 9-[2'-O-benzoyl-3'-O-((2-cyanoethoxy)(diisopropylamino)phosphino)-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N2-isobutyrylguanine (253875-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 280 mg / CH₂Cl₂ / 1 h / 0 °C

2: 70 percent / 2,4,6-collidine; N-methylimidazole / CH₂Cl₂ / 20 °C

With 1-methyl-1H-imidazole; 2,4,6-trimethyl-pyridine; In dichloromethane;

DOI:10.1016/S0968-0896(01)00220-6

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

9-[2'-O-benzoyl-4'-O-((4'',4'''-dimethoxytriphenyl)methyl)-α-lyxopyranosyl-(1')]-N²-isobutyrguanine

benzoyl chloride

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