(2S)-N-benzyl-N-(1,1,1-trifluoro-2-hydroxy-2-phenylprop-3-yl)-8'-aminomenthol

Base Information

Chemical Name:(2S)-N-benzyl-N-(1,1,1-trifluoro-2-hydroxy-2-phenylprop-3-yl)-8'-aminomenthol
CAS No.:881748-31-8
Molecular Formula:C₂₆H₃₄F₃NO₂
Molecular Weight:449.557
Hs Code.:

Synonyms:(2S)-N-benzyl-N-(1,1,1-trifluoro-2-hydroxy-2-phenylprop-3-yl)-8'-aminomenthol

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Chemical Property of (2S)-N-benzyl-N-(1,1,1-trifluoro-2-hydroxy-2-phenylprop-3-yl)-8'-aminomenthol

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Technology Process of (2S)-N-benzyl-N-(1,1,1-trifluoro-2-hydroxy-2-phenylprop-3-yl)-8'-aminomenthol

There total 3 articles about (2S)-N-benzyl-N-(1,1,1-trifluoro-2-hydroxy-2-phenylprop-3-yl)-8'-aminomenthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 881748-12-5
(1S,2S',4a'S,7'R,8a'R)-1-(3-benzyl-4',4',7'-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2'-yl)-2,2,2-trifluoro-1-phenylethanol

: 881748-31-8
(2S)-N-benzyl-N-(1,1,1-trifluoro-2-hydroxy-2-phenylprop-3-yl)-8'-aminomenthol

Guidance literature:: With aluminium trichloride; In tetrahydrofuran; at -10 - 20 ℃;
DOI:10.1021/jo052458v

Reference yield:

: (2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-2-(2,2,2-trifluoro-1-phenyl-1-trimethylsilanyloxy-ethyl)-octahydro-benzo[e][1,3]oxazine

: 881748-31-8
(2S)-N-benzyl-N-(1,1,1-trifluoro-2-hydroxy-2-phenylprop-3-yl)-8'-aminomenthol

Guidance literature:: Multi-step reaction with 2 steps

1: TBAF / tetrahydrofuran / 1 h / 20 °C

2: 95 percent / LiAlH₃; AlCl₃ / tetrahydrofuran / -10 - 20 °C

With aluminium trichloride; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jo052458v

Reference yield:

: 115156-57-5
(2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine

: 881748-31-8
(2S)-N-benzyl-N-(1,1,1-trifluoro-2-hydroxy-2-phenylprop-3-yl)-8'-aminomenthol

Guidance literature:: Multi-step reaction with 3 steps

1: CsF / tetrahydrofuran / 0 °C

2: TBAF / tetrahydrofuran / 1 h / 20 °C

3: 95 percent / LiAlH₃; AlCl₃ / tetrahydrofuran / -10 - 20 °C

With aluminium trichloride; tetrabutyl ammonium fluoride; cesium fluoride; In tetrahydrofuran;
DOI:10.1021/jo052458v