(2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine

Base Information

• Chemical Name: (2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine
• CAS No.: 115156-57-5
• Molecular Formula: C₂₅H₃₁NO₂
• Molecular Weight: 377.527

Synonyms:(2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine

Chemical Property of (2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine

Chemical Property:

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Technology Process of (2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine

There total 1 articles about (2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

phenylglyoxal hydrate (1074-12-0) + (1R,2S,5R)-5-methyl-2-<1-methyl-1-(benzylamino)ethyl>cyclohexan-1-ol (115156-56-4) → (2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine (115156-57-5)

Guidance literature:

In benzene; Heating; water sep. by a Dean-Stark trap;

DOI:10.1016/S0040-4020(01)87677-8

Reference yield: 82.0%

(2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine (115156-57-5) + (trifluoromethyl)trimethylsilane (81290-20-2) → (1R,2S',4a'S,7'R,8a'R)-1-(3-benzyl-4',4',7'-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2'-yl)-2,2,2-trifluoro-1-phenylethanol + (1S,2S',4a'S,7'R,8a'R)-1-(3-benzyl-4',4',7'-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2'-yl)-2,2,2-trifluoro-1-phenylethanol (881748-12-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Further Variations:; Solvents; Product distribution;

DOI:10.1021/jo052458v

Reference yield: 60.0%

(2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine (115156-57-5) → N-benzyl-N-[1-(2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-formamide + (1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol (848033-91-0)

Guidance literature:

In acetonitrile; at 25 ℃; for 4h; Irradiation;

DOI:10.1021/jo0481497

upstream raw materials:

phenylglyoxal hydrate

(1R,2S,5R)-5-methyl-2-<1-methyl-1-(benzylamino)ethyl>cyclohexan-1-ol

Downstream raw materials:

α-methyl-<2S(2α,4aα,7α,8aβ)>-octahydro-α-phenyl-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol

(S)-1-((2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-1-phenyl-ethanol

(S)-1-((2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-1-phenyl-propan-1-ol

α,α-diphenyl-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol

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