2-(4-(1'-(4-methoxybenzyl)-2'-oxospiro[[1,3]dioxolane-2,3'-indolin]-5'-yl)piperazin-1-yl)acetaldehyde

Base Information

Chemical Name:2-(4-(1'-(4-methoxybenzyl)-2'-oxospiro[[1,3]dioxolane-2,3'-indolin]-5'-yl)piperazin-1-yl)acetaldehyde
CAS No.:1612146-57-2
Molecular Formula:C₂₄H₂₇N₃O₅
Molecular Weight:437.495
Hs Code.:

Synonyms:2-(4-(1'-(4-methoxybenzyl)-2'-oxospiro[[1,3]dioxolane-2,3'-indolin]-5'-yl)piperazin-1-yl)acetaldehyde

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Chemical Property of 2-(4-(1'-(4-methoxybenzyl)-2'-oxospiro[[1,3]dioxolane-2,3'-indolin]-5'-yl)piperazin-1-yl)acetaldehyde

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Technology Process of 2-(4-(1'-(4-methoxybenzyl)-2'-oxospiro[[1,3]dioxolane-2,3'-indolin]-5'-yl)piperazin-1-yl)acetaldehyde

There total 5 articles about 2-(4-(1'-(4-methoxybenzyl)-2'-oxospiro[[1,3]dioxolane-2,3'-indolin]-5'-yl)piperazin-1-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1612146-56-1
5'-(4-(2-hydroxyethyl)piperazin-1-yl)-1'-(4-methoxybenzyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one

: 1612146-57-2
2-(4-(1'-(4-methoxybenzyl)-2'-oxospiro[[1,3]dioxolane-2,3'-indolin]-5'-yl)piperazin-1-yl)acetaldehyde

Guidance literature:: 5'-(4-(2-hydroxyethyl)piperazin-1-yl)-1'-(4-methoxybenzyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 1.5h;

Reference yield:

: 75822-54-7
5’-bromo-1‘,2’-dihydrospiro[1,3-dioxolane-2,3’-indole]-2’-one

: 1612146-57-2
2-(4-(1'-(4-methoxybenzyl)-2'-oxospiro[[1,3]dioxolane-2,3'-indolin]-5'-yl)piperazin-1-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 12 h

2.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 12 h / 110 °C

3.1: potassium carbonate / acetonitrile / 12 h / Reflux

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

4.2: 1.5 h / -78 - 20 °C

With oxalyl dichloride; palladium diacetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; dimethyl sulfoxide; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 1612146-57-2
2-(4-(1'-(4-methoxybenzyl)-2'-oxospiro[[1,3]dioxolane-2,3'-indolin]-5'-yl)piperazin-1-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux

2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 12 h

3.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 12 h / 110 °C

4.1: potassium carbonate / acetonitrile / 12 h / Reflux

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

5.2: 1.5 h / -78 - 20 °C

With oxalyl dichloride; palladium diacetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; dimethyl sulfoxide; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;