3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride

Base Information

Chemical Name:3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride
CAS No.:1239957-19-7
Molecular Formula:C₂₉H₂₉ClF₃N₃O₂S*ClH
Molecular Weight:612.543
Hs Code.:

3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride

Synonyms:3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride

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Chemical Property of 3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride

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Technology Process of 3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride

There total 6 articles about 3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1239963-60-0
2-(4-(3-azidopropoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)-propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 1239957-19-7
3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; for 5h; under 2068.65 - 2327.23 Torr;

Reference yield:

: 1239964-55-6
4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzyl methanesulfonate

: 1239957-19-7
3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / acetonitrile / 2 h

2: tetrabutyl ammonium fluoride / tetrahydrofuran

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

4: sodium azide / N,N-dimethyl-formamide / 16 h / 0 °C

5: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 5 h / 2068.65 - 2327.23 Torr

With hydrogenchloride; sodium azide; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1239957-10-8
3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-ol

: 1239957-19-7
3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: sodium azide / N,N-dimethyl-formamide / 16 h / 0 °C

3: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 5 h / 2068.65 - 2327.23 Torr

With hydrogenchloride; sodium azide; hydrogen; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;