1-benzyl-2,2-diethylpiperidine

Base Information

• Chemical Name: 1-benzyl-2,2-diethylpiperidine
• CAS No.: 1228468-96-9
• Molecular Formula: C₁₆H₂₅N
• Molecular Weight: 231.381

Synonyms:1-benzyl-2,2-diethylpiperidine

Chemical Property of 1-benzyl-2,2-diethylpiperidine

Chemical Property:

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Technology Process of 1-benzyl-2,2-diethylpiperidine

There total 7 articles about 1-benzyl-2,2-diethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-benzyl-2-piperidinone (4783-65-7) + ethylmagnesium bromide (925-90-6) → 1-benzyl-2,2-diethylpiperidine (1228468-96-9)

Guidance literature:

N-benzyl-2-piperidinone; With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 ℃; for 0.75h;

ethylmagnesium bromide; In diethyl ether; dichloromethane; at -78 - 20 ℃;

DOI:10.1002/anie.201000652

Reference yield: 66.0%

n-butyl magnesium bromide (693-03-8) + N-benzyl-2-piperidinone (4783-65-7) + ethylmagnesium bromide (925-90-6) → 1-benzyl-2,2-diethylpiperidine (1228468-96-9) + 1-benzyl-2-butyl-2-ethylpiperidine (1228469-00-8)

Guidance literature:

N-benzyl-2-piperidinone; With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 ℃; for 0.75h;

n-butyl magnesium bromide; In diethyl ether; dichloromethane; at -78 - 20 ℃;

ethylmagnesium bromide; In diethyl ether; dichloromethane; at 20 ℃; for 3h;

DOI:10.1002/anie.201000652

Reference yield:

1-benzyl-6-methylsulfanyl-2,3,4,5-tetrahydropyridinium iodide + ethylcerium dichloride (135738-30-6) → 1-benzyl-2,2-diethylpiperidine (1228468-96-9)

Guidance literature:

In tetrahydrofuran; for 6h; Inert atmosphere; Sonication;

DOI:10.1016/j.saa.2013.09.108

upstream raw materials:

n-butyl magnesium bromide

N-benzyl-2-piperidinone

ethylmagnesium bromide

piperidin-2-one

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