1,3-dimethyl-6-<4-<3-<4-<(methylsulfonyl)amino>phenoxy>propyl>piperazin-1-yl>-2,4(1H,3H)-pyrimidinedione

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Chemical Name:1,3-dimethyl-6-<4-<3-<4-<(methylsulfonyl)amino>phenoxy>propyl>piperazin-1-yl>-2,4(1H,3H)-pyrimidinedione
CAS No.:138539-83-0
Molecular Formula:C₂₀H₂₉N₅O₅S
Molecular Weight:451.547
Hs Code.:

Synonyms:1,3-dimethyl-6-<4-<3-<4-<(methylsulfonyl)amino>phenoxy>propyl>piperazin-1-yl>-2,4(1H,3H)-pyrimidinedione

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Chemical Property of 1,3-dimethyl-6-<4-<3-<4-<(methylsulfonyl)amino>phenoxy>propyl>piperazin-1-yl>-2,4(1H,3H)-pyrimidinedione

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Technology Process of 1,3-dimethyl-6-<4-<3-<4-<(methylsulfonyl)amino>phenoxy>propyl>piperazin-1-yl>-2,4(1H,3H)-pyrimidinedione

There total 5 articles about 1,3-dimethyl-6-<4-<3-<4-<(methylsulfonyl)amino>phenoxy>propyl>piperazin-1-yl>-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 138539-81-8
6-<4-<3-(4-aminophenoxy)propyl>piperazin-1-yl>-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

: 138539-84-1
1,3-dimethyl-6-[4-(3-[4-methanesulfonylaminophenoxy]propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione.hydrochloride

: 138539-83-0
1,3-dimethyl-6-<4-<3-<4-<(methylsulfonyl)amino>phenoxy>propyl>piperazin-1-yl>-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With pyridine; sodium hydroxide; chloro-trimethyl-silane; potassium carbonate; In 1,4-dioxane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water;

Reference yield:

: 13094-50-3
1-(3-bromopropoxy)-4-nitrobenzene

: 138539-83-0
1,3-dimethyl-6-<4-<3-<4-<(methylsulfonyl)amino>phenoxy>propyl>piperazin-1-yl>-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 3 h / Heating

2: H₂ / 10percent Pd/C / methanol / 0.5 h / 760 Torr

3: 1.) pyridine, trimethylsilyl chloride / 1.) dioxane, 0 deg C, 5 min., RT, 30 min., 2.) dioxane, 0 deg C, 5 min., RT, 1 h

With pyridine; chloro-trimethyl-silane; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm00096a003

Reference yield:

: 80210-72-6
1,3-dimethyl-6-(piperazine-1-yl)-2,4(1H,3H)-pyrimidinedione

: 138539-83-0
1,3-dimethyl-6-<4-<3-<4-<(methylsulfonyl)amino>phenoxy>propyl>piperazin-1-yl>-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 3 h / Heating

2: H₂ / 10percent Pd/C / methanol / 0.5 h / 760 Torr

3: 1.) pyridine, trimethylsilyl chloride / 1.) dioxane, 0 deg C, 5 min., RT, 30 min., 2.) dioxane, 0 deg C, 5 min., RT, 1 h

With pyridine; chloro-trimethyl-silane; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm00096a003