1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-3-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]pyrrolidin-2-one

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Chemical Name:1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-3-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]pyrrolidin-2-one
CAS No.:1613395-16-6
Molecular Formula:C₂₅H₂₃FN₈O
Molecular Weight:470.509
Hs Code.:

Synonyms:1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-3-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]pyrrolidin-2-one

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Chemical Property of 1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-3-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]pyrrolidin-2-one

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Technology Process of 1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-3-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]pyrrolidin-2-one

There total 6 articles about 1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-3-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1613396-23-8
3-[3-(4,5-dihydro-1H-imidazol-2-yl)pyrazolo[3 ,4-b]pyridin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one

: 1613395-16-6
1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-3-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]pyrrolidin-2-one

Guidance literature:: With Dess-Martin periodane; In dimethyl sulfoxide; at 80 ℃; for 1h;

Reference yield:

: 1512322-11-0
1-(4-fluorophenyl)-5-isopropyl-1H-pyrazol-4-amine

: 1613395-16-6
1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-3-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 2.75 h / 20 - 50 °C

2: triethylamine / dichloromethane / 0.67 h / 0 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 50 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

5: acetic acid / ethanol / 1 h / 100 °C

6: Dess-Martin periodane / dimethyl sulfoxide / 1 h / 80 °C

With trimethylaluminum; sodium hydride; potassium carbonate; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1613396-15-8
2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide

: 1613395-16-6
1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-3-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.67 h / 0 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 50 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

4: acetic acid / ethanol / 1 h / 100 °C

5: Dess-Martin periodane / dimethyl sulfoxide / 1 h / 80 °C

With sodium hydride; potassium carbonate; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;