(3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone
CAS No.:827008-47-9
Molecular Formula:C₂₀H₁₉F₃N₄OS
Molecular Weight:420.458
Hs Code.:

Synonyms:(3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone

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Chemical Property of (3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone

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Technology Process of (3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone

There total 6 articles about (3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 109-01-3
1-methyl-piperazine

: 299165-10-9
ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester

: 827008-47-9
(3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: With potassium carbonate; In neat (no solvent); at 100 ℃;
DOI:10.1002/jhet.3578

Reference yield:

: 109-01-3
1-methyl-piperazine

: 104960-56-7
3-amino-2-carboxy-4-trifluoromethyl-6-phenylthieno<2,3-b>pyridine

: 827008-47-9
(3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2014.01.075

Reference yield:

: 104960-49-8
2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 827008-47-9
(3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / N,N-dimethyl-formamide; water / 20 °C

2: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.01.075