2',3'-dihydro-6'-(phenylethynyl)-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1'(5'H)-indolizine>

Base Information

Chemical Name:2',3'-dihydro-6'-(phenylethynyl)-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1'(5'H)-indolizine>
CAS No.:88761-53-9
Molecular Formula:C₂₁H₂₁NO₃
Molecular Weight:335.403
Hs Code.:

Synonyms:2',3'-dihydro-6'-(phenylethynyl)-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1'(5'H)-indolizine>

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Chemical Property of 2',3'-dihydro-6'-(phenylethynyl)-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1'(5'H)-indolizine>

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Technology Process of 2',3'-dihydro-6'-(phenylethynyl)-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1'(5'H)-indolizine>

There total 7 articles about 2',3'-dihydro-6'-(phenylethynyl)-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1'(5'H)-indolizine> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 88761-46-0
2',3'-dihydro-6'-iodo-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1(5'H)-indolizine>

: 536-74-3
phenylacetylene

: 88761-53-9
2',3'-dihydro-6'-(phenylethynyl)-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1'(5'H)-indolizine>

Guidance literature:: With triethylamine; triphenylphosphine; bis(benzonitrile)palladium(II) dichloride; for 3h; Heating;
DOI:10.1021/jo00199a009

Reference yield:

: 18270-17-2
1-trimethylsilyl-1-pentyne

: 88761-53-9
2',3'-dihydro-6'-(phenylethynyl)-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1'(5'H)-indolizine>

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / CpCo(CO)2 / xylene / Heating; Irradiation

2: 93 percent / ICl / CH₂Cl₂ / 0 °C

3: 95 percent / Pd

With dicarbonylcyclopentadienylcobalt; Iodine monochloride; palladium; In dichloromethane; xylene;
DOI:10.1021/ja00361a057

Reference yield:

: 92958-07-1
methyl 2-<(trimethylsilyl)ethynyl>-1,3-dioxolane-2-propanoate

: 88761-53-9
2',3'-dihydro-6'-(phenylethynyl)-7'-propyl-5'-oxospiro<1,3-dioxolane-2,1'(5'H)-indolizine>

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaOH, 2.) (COCl)2, DMF / 1.) CH₃OH, H₂O, 2.) C₆H₆, 25 - 35 deg C

2: 84 percent / NaN₃ / acetonitrile / 0.5 h / Heating

3: 60 percent / CpCo(CO)2 / xylene / Heating; Irradiation

4: 93 percent / ICl / CH₂Cl₂ / 0 °C

5: 95 percent / Pd

With sodium hydroxide; sodium azide; oxalyl dichloride; dicarbonylcyclopentadienylcobalt; Iodine monochloride; N,N-dimethyl-formamide; palladium; In dichloromethane; acetonitrile; xylene;
DOI:10.1021/ja00361a057