18270-17-2

Basic information

• Product Name: 1-(TRIMETHYLSILYL)-1-PENTYNE
• Synonyms: 1-PENTYN-1-YLTRIMETHYLSILANE;1-(TRIMETHYLSILYL)-1-PENTYNE;TIMTEC-BB SBB009062;trimethyl(pent-1-ynyl)silane;1-TMS-1-pentyne 1-Pentyn-1-yltrimethylsilane;Trimethyl(pent-1-yn-1-yl)silane;TriMethylsilyl-1-pent
• CAS NO: 18270-17-2
• Molecular Formula: C₈H₁₆Si
• Molecular Weight: 140.3
• Product Categories: Alkynes;Building Blocks;Chemical Synthesis;Internal;Organic Building Blocks
• Mol File: 18270-17-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 135 °C(lit.)
• Flash Point: 73 °F
• Appearance: /
• Density: 0.765 g/mL at 25 °C(lit.)
• Vapor Pressure: 9.73mmHg at 25°C
• Refractive Index: n20/D 1.425(lit.)
• BRN: 1744218
• CAS DataBase Reference: 1-(TRIMETHYLSILYL)-1-PENTYNE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TRIMETHYLSILYL)-1-PENTYNE(18270-17-2)
• EPA Substance Registry System: 1-(TRIMETHYLSILYL)-1-PENTYNE(18270-17-2)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.1
• PackingGroup: II
• Hazardous Substances Data: 18270-17-2(Hazardous Substances Data)

Usage

General Description

1-(Trimethylsilyl)-1-pentyne is a specialty chemical often used in organic chemistry as a protecting agent or a reagent in the synthesis of more complex organic compounds. Composed of carbon, hydrogen, and silicon atoms, it is known for its volatile nature and low reactivity making it ideal for various chemical reactions. It has a molecular formula of C8H16Si and its exact mass is 140.09862. The compound typically appears as a clear, colorless liquid, and must be handled carefully due to its highly reactive properties. Precautions should also be taken to prevent direct exposure, as it may cause skin, eye, or respiratory irritation.

InChI:InChI=1/C8H16Si/c1-5-6-7-8-9(2,3)4/h5-6H2,1-4H3

Upstream product

• 60-29-7 diethyl ether 
• 2696-32-4 but-3-en-1-ynyl-trimethyl-silane 
• 917-54-4 methyllithium 
• 107-08-4 1-iodo-propane 
• 1066-54-2 trimethylsilylacetylene 
• 75-79-6 Methyltrichlorosilane 
• 41246-05-3 pent-1-ynyl-magnesium bromide 
• 75-77-4 chloro-trimethyl-silane 
• 14267-92-6 1-chloro-4-pentyne 
• 14752-59-1 1-chloro-pent-1-yne 
• 627-19-0 1-Pentyne 
• 59323-36-3 1,2-dichloro-cyclopentene 

Downstream Products

• 31844-95-8 2-bromopent-1-ene 
• 627-19-0 1-Pentyne 
• 1733-15-9 Tetramethyl ethylenetetracarboxylate 
• 105937-50-6 2-methoxycarbonyle-7-trimethylsilyle hept-6-ynoate de methyle 
• 132796-98-6 [(Z)-1-(4-Methoxy-phenyl)-pent-1-enyl]-trimethyl-silane 

Relevant articles and documents

Catalytic Decarboxylation of Silyl Alkynoates to Alkynylsilanes

Herein, we describe a decarboxylative approach to the preparation of alkynylsilanes. Treatment of a silyl alkynoate in N,N-dimethylformamide (DMF) at 80 °C in the presence of catalytic amounts of CuCl and PCy3 produced the corresponding alkynylsilane in excellent yield. The copper-catalyzed decarboxylation proceeded smoothly with low catalyst loadings (0.5 mol % of CuCl and 1.0 mol % of PCy3) under mild reaction conditions and is easily scalable to gram quantities.

TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.

Reactions of 1,2-dihalocycloalkenes with alkali metals in presence of chlorotrimethylsilane. Reductive carbon-carbon bond cleavage in five membered homocyclic system

1,2-Dihalocyclopentenes on reaction with alkali metals and chlorotrimethylsilane in hydrocarbon or ether solvents produce silylated 1-pentynes by ring opening. Sodium metal and hydrocarbon solvents favour the cleavage most. Different mechanistic aspects are considered.