Technology Process of 8-Bromo-2-(2-cyano-1-hydroxyethyl)quinolin-7-yl benzenesulfonate
There total 4 articles about 8-Bromo-2-(2-cyano-1-hydroxyethyl)quinolin-7-yl benzenesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-trimethylsilylacetonitrile; 8-bromo-2-formylquinolin-7-yl benzenesulfonate;
With
lithium acetate;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
With
citric acid;
In
methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14.16 h / 0 - 20 °C / Inert atmosphere
2: selenium(IV) oxide / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere
3: lithium acetate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
With
selenium(IV) oxide; lithium acetate; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: selenium(IV) oxide / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere
2: lithium acetate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
With
selenium(IV) oxide; lithium acetate;
In
1,4-dioxane; N,N-dimethyl-formamide;
