{(8R)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol

Base Information

• Chemical Name: {(8R)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol
• CAS No.: 1403395-90-3
• Molecular Formula: C₂₀H₂₂N₄O₂S
• Molecular Weight: 382.486
• Mol file: 1403395-90-3.mol

Synonyms:{(8R)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol

Chemical Property of {(8R)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(8R)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol

There total 6 articles about {(8R)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine (1403396-94-0) → {(8R)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol (1403395-90-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃;

Reference yield:

4-Bromophenylacetonitrile (16532-79-9) → {(8R)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol (1403395-90-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 3 h / 50 °C

1.2: 72 h / 100 °C

2.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

4.1: butan-1-ol / 6 h / 140 °C / Inert atmosphere

5.1: lithium tert-butoxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / Reflux

6.1: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-benzyl-N,N,N-triethylammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; lithium tert-butoxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

1-(4-bromophenyl)cyclopropanecarboxylic acid (345965-52-8) → {(8R)-8-methyl-3-{1-[4-(1,3-oxazol-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol (1403395-90-3)

Guidance literature:

Multi-step reaction with 5 steps

1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 20 °C

2: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

3: butan-1-ol / 6 h / 140 °C / Inert atmosphere

4: lithium tert-butoxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / Reflux

5: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium tert-butoxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; butan-1-ol;

upstream raw materials:

4-Bromophenylacetonitrile

1-(4-bromophenyl)cyclopropanecarboxylic acid

tert-butyl 2-{[1-(4-bromophenyl)cyclopropyl]carbonyl}hydrazinecarboxylate

1-(4-bromophenyl)cyclopropanecarbohydrazide