N-[2,3-bis(benzyloxy)-6-bromo-benzylidene]naphtho-[2,3-d][1,3]dioxol-5-amine

Base Information

• Chemical Name: N-[2,3-bis(benzyloxy)-6-bromo-benzylidene]naphtho-[2,3-d][1,3]dioxol-5-amine
• CAS No.: 1432677-41-2
• Molecular Formula: C₃₂H₂₄BrNO₄
• Molecular Weight: 566.451
• Mol file: 1432677-41-2.mol

Synonyms:N-[2,3-bis(benzyloxy)-6-bromo-benzylidene]naphtho-[2,3-d][1,3]dioxol-5-amine

Chemical Property of N-[2,3-bis(benzyloxy)-6-bromo-benzylidene]naphtho-[2,3-d][1,3]dioxol-5-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2,3-bis(benzyloxy)-6-bromo-benzylidene]naphtho-[2,3-d][1,3]dioxol-5-amine

There total 3 articles about N-[2,3-bis(benzyloxy)-6-bromo-benzylidene]naphtho-[2,3-d][1,3]dioxol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

naphtho[2,3-d][1,3]dioxol-5-amine (53811-49-7) + 2,3-Bis(benzyloxy)-6-bromobenzaldehyde (1432677-40-1) → N-[2,3-bis(benzyloxy)-6-bromo-benzylidene]naphtho-[2,3-d][1,3]dioxol-5-amine (1432677-41-2)

Guidance literature:

In toluene; for 4h; Reflux;

DOI:10.1016/j.tet.2013.03.105

Reference yield:

6-bromo-2,3-dihydroxybenzaldehyde (83983-71-5) → N-[2,3-bis(benzyloxy)-6-bromo-benzylidene]naphtho-[2,3-d][1,3]dioxol-5-amine (1432677-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethanol / 12 h / Inert atmosphere; Reflux

2: toluene / 4 h / Reflux

With potassium carbonate; In ethanol; toluene;

DOI:10.1016/j.tet.2013.03.105

Reference yield:

6-bromo-2-hydroxy-3-methoxybenzaldehyde (20035-41-0) → N-[2,3-bis(benzyloxy)-6-bromo-benzylidene]naphtho-[2,3-d][1,3]dioxol-5-amine (1432677-41-2)

Guidance literature:

Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 2 h / 20 °C

2: potassium carbonate / ethanol / 12 h / Inert atmosphere; Reflux

3: toluene / 4 h / Reflux

With boron tribromide; potassium carbonate; In ethanol; dichloromethane; toluene;

DOI:10.1016/j.tet.2013.03.105

upstream raw materials:

6-bromo-2,3-dihydroxybenzaldehyde

naphtho[2,3-d][1,3]dioxol-5-amine

2,3-Bis(benzyloxy)-6-bromobenzaldehyde

6-bromo-2-hydroxy-3-methoxybenzaldehyde

Downstream raw materials:

N-[2,3-bis(benzyloxy)-6-bromo-benzyl]naphtho[2,3-d][1,3]dioxol-5-amine

13-ethoxy-1,2-bis(benzyloxy)-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine

1,2-bis(benzyloxy)-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine