ethyl 4-(3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-6-hydroxy-3-methoxy-2-methylbenzoate

Base Information

• Chemical Name: ethyl 4-(3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-6-hydroxy-3-methoxy-2-methylbenzoate
• CAS No.: 146984-80-7
• Molecular Formula: C₁₉H₁₉ClO₈
• Molecular Weight: 410.808
• Mol file: 146984-80-7.mol

Synonyms:ethyl 4-(3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-6-hydroxy-3-methoxy-2-methylbenzoate

Chemical Property of ethyl 4-(3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-6-hydroxy-3-methoxy-2-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-6-hydroxy-3-methoxy-2-methylbenzoate

There total 4 articles about ethyl 4-(3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-6-hydroxy-3-methoxy-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

3-chloro-6-hydroxy-2-methoxybenzoic acid (146984-79-4) + ethyl 4,6-dihydroxy-3-methoxy-2-methylbenzoate (146984-71-6) → ethyl 4-(3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-6-hydroxy-3-methoxy-2-methylbenzoate (146984-80-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In diethyl ether; toluene; for 40h; Ambient temperature;

Reference yield:

methyl 6-methoxysalicylate (22833-69-8) → ethyl 4-(3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-6-hydroxy-3-methoxy-2-methylbenzoate (146984-80-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 29 percent / SO₂Cl₂ / diethyl ether / 22 h / Ambient temperature

2: 40 percent / aq. KOH / dimethylsulfoxide / 4.5 h / 100 - 115 °C

3: 19 percent / DCC / toluene; diethyl ether / 40 h / Ambient temperature

With potassium hydroxide; sulfuryl dichloride; dicyclohexyl-carbodiimide; In diethyl ether; dimethyl sulfoxide; toluene;

Reference yield:

ethyl 4-benzyloxy-3,6-dimethoxy-2-methylbenzoate (65614-44-0) → ethyl 4-(3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-6-hydroxy-3-methoxy-2-methylbenzoate (146984-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / BCl₃ / CH₂Cl₂ / 0.25 h / 0 °C

2: 19 percent / DCC / toluene; diethyl ether / 40 h / Ambient temperature

With boron trichloride; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane; toluene;

upstream raw materials:

3-chloro-6-hydroxy-2-methoxybenzoic acid

ethyl 4,6-dihydroxy-3-methoxy-2-methylbenzoate

methyl 6-methoxysalicylate

ethyl 4-benzyloxy-3,6-dimethoxy-2-methylbenzoate

Downstream raw materials:

3-chloro-6-(4'-ethoxycarbonyl-5'-hydroxy-2'-methoxy-3'-methylphenoxy)-2-methoxybenzoic acid