METHYL 2-HYDROXY-6-METHOXYBENZOATE

Base Information

• Chemical Name: METHYL 2-HYDROXY-6-METHOXYBENZOATE
• CAS No.: 22833-69-8
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• Hs Code.: 2918990090
• Mol file: 22833-69-8.mol

Synonyms:2-hydroxy-6-methoxybenzoic acid methyl ester;6-methoxysalicylic acid methyl ester;methyl 6-methoxysalicylate;methyl 2-hydroxy-6-methoxy-benzoate;2-Hydroxy-6-methoxybenzoesaeuremethylester;

Chemical Property of METHYL 2-HYDROXY-6-METHOXYBENZOATE

Chemical Property:

• Melting Point: 50-52 °C
• Boiling Point: 134-138 °C(Press: 9 Torr)
• PKA: 9.38±0.10(Predicted)
• PSA: 55.76000
• Density: 1.216±0.06 g/cm3(Predicted)
• LogP: 1.18740
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Hydroxy-6-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-HYDROXY-6-METHOXYBENZOATE

There total 14 articles about METHYL 2-HYDROXY-6-METHOXYBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 2,6-dimethoxybenzoate (2065-27-2) → methyl 6-methoxysalicylate (22833-69-8)

Guidance literature:

With boron trichloride; In dichloromethane;

DOI:10.1016/j.tetlet.2018.11.055

Reference yield: 97.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-hydroxy-6-methoxybenzoic acid (3147-64-6) → methyl 6-methoxysalicylate (22833-69-8)

Guidance literature:

In diethyl ether; at -78 ℃; for 0.5h;

DOI:10.1021/jo500234w

Reference yield: 94.0%

2-hydroxy-6-methoxybenzoic acid (3147-64-6) + methyl iodide (74-88-4) → methyl 6-methoxysalicylate (22833-69-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 - 23 ℃; for 19h;

DOI:10.1055/s-2001-16056

upstream raw materials:

methyl 2,6-dihydroxybenzoate

methanol

methyl 2-methoxy-6-(methoxymethoxy)benzoate

2-hydroxy-6-methoxybenzoic acid

Downstream raw materials:

methyl 2-methoxy-6-{[(trifluoromethyl)sulfonyl]oxy}benzoate

methyl 3-chloro-6-hydroxy-2-methoxybenzoate

methyl 3-chloro-2-hydroxy-6-methoxybenzoate

methyl 2-(t-butyldimethylsiloxy)-6-methoxybenzoate