(S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate

Base Information

Chemical Name:(S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate
CAS No.:140677-48-1
Molecular Formula:C₂₃H₃₁N₃O₈
Molecular Weight:477.514
Hs Code.:

Synonyms:(S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate

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Chemical Property of (S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate

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Technology Process of (S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate

There total 4 articles about (S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 6945-92-2
2-hydrazinyl acetic acid ethyl ester hydrochloride

: 140677-44-7
(S)-3-(benzyloxycarbonyl)-4-(6,6-(ethylenedioxy)-3-oxohexyl)oxazolidin-5-one

: 140677-48-1
(S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate

Guidance literature:: With sodium acetate; In methanol; at 50 ℃; for 0.5h;
DOI:10.1021/jo00039a007

Reference yield:

: 18742-02-4
2-bromo-2-(2-ethyl)dioxolane

: 140677-48-1
(S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Mg / 1) THF, r.t., 30 min, 2) THF, -65 deg C, 1 h

2: 12 percent / NaOAc / methanol / 0.5 h / 50 °C

With sodium acetate; magnesium; In methanol;
DOI:10.1021/jo00039a007

Reference yield:

: 23632-67-9
(S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid

: 140677-48-1
(S)-ethyl 6-((benzyloxycarbonyl)(hydroxymethyl)amino)-3-((3,3-ethylenedioxy)propyl)-7-oxo-4,5,6,7-tetrahydro-1H-1,2-diazepine-1-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / SOCl₂ / CH₂Cl₂; dimethylformamide / 2 h / Ambient temperature

2: 1) Mg / 1) THF, r.t., 30 min, 2) THF, -65 deg C, 1 h

3: 12 percent / NaOAc / methanol / 0.5 h / 50 °C

With thionyl chloride; sodium acetate; magnesium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00039a007