(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetylamino}-2-butoxycarbonylamino-propionic acid methyl ester

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Chemical Name:(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetylamino}-2-butoxycarbonylamino-propionic acid methyl ester
CAS No.:190446-83-4
Molecular Formula:C₂₆H₃₅N₅O₈
Molecular Weight:545.593
Hs Code.:

Synonyms:(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetylamino}-2-butoxycarbonylamino-propionic acid methyl ester

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Chemical Property of (S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetylamino}-2-butoxycarbonylamino-propionic acid methyl ester

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Technology Process of (S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetylamino}-2-butoxycarbonylamino-propionic acid methyl ester

There total 8 articles about (S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetylamino}-2-butoxycarbonylamino-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 169605-35-0
(S)-3-amino-2-butoxycarbonylamino-propionic acid methyl ester

: 190446-82-3
[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid

: 190446-83-4
(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetylamino}-2-butoxycarbonylamino-propionic acid methyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1021/jm960799i

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 190446-83-4
(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetylamino}-2-butoxycarbonylamino-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / Et₃N / dimethylformamide / 64 h / Ambient temperature

2: 70 percent / aq. LiOH*H₂O / methanol / 16 h / Ambient temperature

3: 76 percent / TBTU, Et₃N / dimethylformamide / 16 h / Ambient temperature

With lithium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i

Reference yield:

: 170229-12-6
[3-(4-Cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester

: 190446-83-4
(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetylamino}-2-butoxycarbonylamino-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NBS, AIBN / CHCl₃ / Heating

2: KOAc, HOAc / CHCl₃ / 1 h / Heating

3: 82 percent / HCl gas / 24 h / Ambient temperature

4: 100 percent / NH₃ / methanol / 24 h / Ambient temperature

5: 54 percent / Et₃N / dimethylformamide / 64 h / Ambient temperature

6: 70 percent / aq. LiOH*H₂O / methanol / 16 h / Ambient temperature

7: 76 percent / TBTU, Et₃N / dimethylformamide / 16 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; potassium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i