[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid

Base Information

Chemical Name:[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid
CAS No.:190446-82-3
Molecular Formula:C₁₇H₁₉N₃O₅
Molecular Weight:345.355
Hs Code.:

Synonyms:[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid

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Chemical Property of [3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid

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Technology Process of [3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid

There total 7 articles about [3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 190446-81-2
[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid methyl ester

: 190446-82-3
[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid

Guidance literature:: With lithium hydroxide; In methanol; for 16h; Ambient temperature;
DOI:10.1021/jm960799i

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 190446-82-3
[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / Et₃N / dimethylformamide / 64 h / Ambient temperature

2: 70 percent / aq. LiOH*H₂O / methanol / 16 h / Ambient temperature

With lithium hydroxide; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i

Reference yield:

: 170229-12-6
[3-(4-Cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester

: 190446-82-3
[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-isoxazol-5-yl]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: NBS, AIBN / CHCl₃ / Heating

2: KOAc, HOAc / CHCl₃ / 1 h / Heating

3: 82 percent / HCl gas / 24 h / Ambient temperature

4: 100 percent / NH₃ / methanol / 24 h / Ambient temperature

5: 54 percent / Et₃N / dimethylformamide / 64 h / Ambient temperature

6: 70 percent / aq. LiOH*H₂O / methanol / 16 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; potassium acetate; acetic acid; triethylamine; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i