1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1719-33-1
Molecular Formula:C₁₈H₂₁NO₃
Molecular Weight:299.37
Hs Code.:

Synonyms:1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 12 articles about 1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1871-08-5
1-(3-benzyloxybenzyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 1719-33-1
1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; for 16h;
DOI:10.1021/jo201056f

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1719-33-1
1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium acetate / acetic acid / 5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 3 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

5.1: sodium hydroxide / chloroform / 0 - 20 °C

6.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere

6.2: 20 °C / Inert atmosphere; Cooling with ice

7.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 16 h

With lithium aluminium tetrahydride; palladium 10% on activated carbon; ammonium acetate; hydrogen; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetic acid; acetonitrile; 1.1: Henry reaction / 5.1: Schotten-Baumann reaction / 6.1: Bischler-Napieralski cyclization;
DOI:10.1021/jo201056f

Reference yield:

: 22231-61-4
2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine

: 1719-33-1
1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 3 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3.1: sodium hydroxide / chloroform / 0 - 20 °C

4.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere

4.2: 20 °C / Inert atmosphere; Cooling with ice

5.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 16 h

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetonitrile; 3.1: Schotten-Baumann reaction / 4.1: Bischler-Napieralski cyclization;
DOI:10.1021/jo201056f