2-(3-benzyloxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide

Base Information

Chemical Name:2-(3-benzyloxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide
CAS No.:1316258-93-1
Molecular Formula:C₃₂H₃₃NO₄
Molecular Weight:495.618
Hs Code.:

Synonyms:2-(3-benzyloxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide

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Chemical Property of 2-(3-benzyloxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide

Chemical Property:

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Technology Process of 2-(3-benzyloxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide

There total 8 articles about 2-(3-benzyloxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 1316258-93-1
2-(3-benzyloxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / ethanol / 20 h / 20 °C / Inert atmosphere

2: ammonium acetate / acetic acid / 5 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 3 h / 20 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

6: sodium hydroxide / chloroform / 0 - 20 °C

With lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; acetic acid; 2: Henry reaction / 6: Schotten-Baumann reaction;
DOI:10.1021/jo201056f

Reference yield:

: 22231-61-4
2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine

: 1316258-93-1
2-(3-benzyloxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3: sodium hydroxide / chloroform / 0 - 20 °C

With lithium aluminium tetrahydride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; chloroform; 3: Schotten-Baumann reaction;
DOI:10.1021/jo201056f

Reference yield:

: 621-37-4
m-hydroxyphenylacetic acid

: 1316258-93-1
2-(3-benzyloxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium iodide; potassium hydroxide / ethanol / 90 °C

1.2: 16 h / 100 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / chloroform / 0 - 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; In ethanol; chloroform; toluene; 3.1: Schotten-Baumann reaction;
DOI:10.1021/jo201056f