(Z)-N,N-diethyl-2-(2-hydroxy-3-(trimethylsilyl)phenyl)-3-phenylacrylamide

Base Information

Chemical Name:(Z)-N,N-diethyl-2-(2-hydroxy-3-(trimethylsilyl)phenyl)-3-phenylacrylamide
CAS No.:741695-53-4
Molecular Formula:C₂₂H₂₉NO₂Si
Molecular Weight:367.563
Hs Code.:

Synonyms:(Z)-N,N-diethyl-2-(2-hydroxy-3-(trimethylsilyl)phenyl)-3-phenylacrylamide

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Chemical Property of (Z)-N,N-diethyl-2-(2-hydroxy-3-(trimethylsilyl)phenyl)-3-phenylacrylamide

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Technology Process of (Z)-N,N-diethyl-2-(2-hydroxy-3-(trimethylsilyl)phenyl)-3-phenylacrylamide

There total 12 articles about (Z)-N,N-diethyl-2-(2-hydroxy-3-(trimethylsilyl)phenyl)-3-phenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 741695-79-4
Diethyl-carbamic acid 2-((Z)-1-bromo-2-phenyl-vinyl)-6-trimethylsilanyl-phenyl ester

: 741695-53-4
(Z)-N,N-diethyl-2-(2-hydroxy-3-(trimethylsilyl)phenyl)-3-phenylacrylamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - -30 ℃;
DOI:10.1021/ol049740t

Reference yield: 94.0%

: 741695-52-3
(E)-2-styryl-6-(trimethylsilyl)phenyl diethylcarbamate

: 741695-53-4
(Z)-N,N-diethyl-2-(2-hydroxy-3-(trimethylsilyl)phenyl)-3-phenylacrylamide

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -10 - 0 ℃; for 4h;
DOI:10.1021/ol049740t

Reference yield:

: 7436-90-0
2,2-dibromostyrene

: 741695-53-4
(Z)-N,N-diethyl-2-(2-hydroxy-3-(trimethylsilyl)phenyl)-3-phenylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / TFP; Na₂CO₃ / Pd₂(dba)3 / H₂O; 1,2-dimethoxy-ethane / Heating

2: 96 percent / n-BuLi / tetrahydrofuran / -78 - -30 °C

With n-butyllithium; sodium carbonate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: Suzuki-Miyaura coupling;
DOI:10.1021/ol049740t