8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate

Base Information

• Chemical Name: 8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate
• CAS No.: 1005187-65-4
• Molecular Formula: C₂₅H₃₃N₃O₈
• Molecular Weight: 503.552
• Mol file: 1005187-65-4.mol

Synonyms:8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate;1005187-65-4;8-O-benzyl 1-O,3-O-ditert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate;SCHEMBL13752779;AKOS025395908;DS-8242;CS-0187276;S10463;A919745;8-Benzyl1,3-di-tert-butyl2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate

Chemical Property of 8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 503.22676502
• Heavy Atom Count: 36
• Complexity: 890

Purity/Quality:

97% ^*data from raw suppliers

8-Benzyl1,3-di-tert-butyl2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1C(=O)C2(CCN(CC2)C(=O)OCC3=CC=CC=C3)N(C1=O)C(=O)OC(C)(C)C

Technology Process of 8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate

There total 2 articles about 8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + 2,4-dioxo-1,3,8-triazaspiro<4.5>decane-8-carboxylic acid benzyl ester (28121-73-5) → 8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate (1005187-65-4)

Guidance literature:

With triethylamine; dmap; In 1,2-dimethoxyethane; at 20 ℃;

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate (1005187-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium carbonate / methanol; water / 72 h / 20 °C / Inert atmosphere

2: triethylamine; dmap / 1,2-dimethoxyethane / 7 h / 20 °C / Inert atmosphere

With dmap; ammonium carbonate; triethylamine; In methanol; 1,2-dimethoxyethane; water;

Reference yield: 79.0%

8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate (1005187-65-4) → N-carbobenzyloxy-4-amino-4-carboxy-piperidine (115655-41-9)

Guidance literature:

8-Benzyl 1,3-di-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In water; at 0 ℃;

upstream raw materials:

di-tert-butyl dicarbonate

2,4-dioxo-1,3,8-triazaspiro<4.5>decane-8-carboxylic acid benzyl ester

benzyl 4-oxo-1-piperidinecarboxylate

Downstream raw materials:

N-carbobenzyloxy-4-amino-4-carboxy-piperidine

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