(Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-hydroxybut-2-enyloxy)phenyl)piperazine-1-carboxylate

Base Information

Chemical Name:(Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-hydroxybut-2-enyloxy)phenyl)piperazine-1-carboxylate
CAS No.:1341209-14-0
Molecular Formula:C₃₀H₃₃N₃O₆
Molecular Weight:531.609
Hs Code.:

Synonyms:(Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-hydroxybut-2-enyloxy)phenyl)piperazine-1-carboxylate

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Chemical Property of (Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-hydroxybut-2-enyloxy)phenyl)piperazine-1-carboxylate

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Technology Process of (Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-hydroxybut-2-enyloxy)phenyl)piperazine-1-carboxylate

There total 4 articles about (Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-hydroxybut-2-enyloxy)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1341209-12-8
(Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-(propionyloxy)but-2-enyloxy)phenyl)piperazine-1-carboxylate

: 1341209-14-0
(Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-hydroxybut-2-enyloxy)phenyl)piperazine-1-carboxylate

Guidance literature:: With methanol; potassium hydroxide; In tetrahydrofuran; at -5 - 20 ℃; for 2h;
DOI:10.1021/jm200614t

Reference yield:

: 911845-36-8
(2Z)-4-(5-bromo-2-nitrophenoxy)but-2-enyl propionate

: 1341209-14-0
(Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-hydroxybut-2-enyloxy)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium fluoride; potassium carbonate / N,N-dimethyl-formamide / 14 h / 120 °C / Molecular sieve

2: tin(II) chloride dihdyrate / ethanol / 18 h / Inert atmosphere; Reflux

3: pyridine / dichloromethane / 2 h / 20 °C

4: methanol; potassium hydroxide / tetrahydrofuran / 2 h / -5 - 20 °C

With pyridine; methanol; potassium fluoride; tin(II) chloride dihdyrate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200614t

Reference yield:

: C₁₇H₂₅N₃O₃

: 1341209-14-0
(Z)-benzyl 4-(4-(benzyloxycarbonylamino)-3-(4-hydroxybut-2-enyloxy)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2 h / 20 °C

2: methanol; potassium hydroxide / tetrahydrofuran / 2 h / -5 - 20 °C

With pyridine; methanol; potassium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm200614t