benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate
• CAS No.: 1341209-18-4
• Molecular Formula: C₃₆H₄₇N₃O₇Si
• Molecular Weight: 661.871

Synonyms:benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate

Chemical Property of benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate

There total 6 articles about benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 4-(4-(benzyloxycarbonylamino)-3-(((2R,3S)-3-(hydroxymethyl)oxiran-2-yl)methoxy)phenyl)piperazine-1-carboxylate (1341209-16-2) + tert-butyldimethylsilyl chloride (18162-48-6) → benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate (1341209-18-4)

Guidance literature:

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

DOI:10.1021/jm200614t

Reference yield:

(2Z)-4-(5-bromo-2-nitrophenoxy)but-2-enyl propionate (911845-36-8) → benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate (1341209-18-4)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium fluoride; potassium carbonate / N,N-dimethyl-formamide / 14 h / 120 °C / Molecular sieve

2: tin(II) chloride dihdyrate / ethanol / 18 h / Inert atmosphere; Reflux

3: pyridine / dichloromethane / 2 h / 20 °C

4: methanol; potassium hydroxide / tetrahydrofuran / 2 h / -5 - 20 °C

5: tert.-butylhydroperoxide; titanium acetate; diethyl (2R,3R)-tartrate / dichloromethane; toluene / 20 h / -40 °C / Molecular sieve

6: 1H-imidazole; dmap / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

With pyridine; 1H-imidazole; methanol; tert.-butylhydroperoxide; dmap; potassium fluoride; titanium acetate; tin(II) chloride dihdyrate; diethyl (2R,3R)-tartrate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 5: Sharpless epoxidation;

DOI:10.1021/jm200614t

Reference yield:

(Z)-4-(2-nitro-5-(piperazin-1-yl)phenoxy)but-2-enyl propionate (1341209-10-6) → benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate (1341209-18-4)

Guidance literature:

Multi-step reaction with 5 steps

1: tin(II) chloride dihdyrate / ethanol / 18 h / Inert atmosphere; Reflux

2: pyridine / dichloromethane / 2 h / 20 °C

3: methanol; potassium hydroxide / tetrahydrofuran / 2 h / -5 - 20 °C

4: tert.-butylhydroperoxide; titanium acetate; diethyl (2R,3R)-tartrate / dichloromethane; toluene / 20 h / -40 °C / Molecular sieve

5: 1H-imidazole; dmap / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

With pyridine; 1H-imidazole; methanol; tert.-butylhydroperoxide; dmap; titanium acetate; tin(II) chloride dihdyrate; diethyl (2R,3R)-tartrate; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4: Sharpless epoxidation;

DOI:10.1021/jm200614t

upstream raw materials:

(2Z)-4-(5-bromo-2-nitrophenoxy)but-2-enyl propionate

benzyl 4-(4-(benzyloxycarbonylamino)-3-(((2R,3S)-3-(hydroxymethyl)oxiran-2-yl)methoxy)phenyl)piperazine-1-carboxylate

tert-butyldimethylsilyl chloride

(Z)-4-(2-nitro-5-(piperazin-1-yl)phenoxy)but-2-enyl propionate

Downstream raw materials:

benzyl 4-[(3R,3aS)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-7-yl]piperazine-1-carboxylate

benzyl 4-[(3R,3aS)-3-(hydroxymethyl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-7-yl]piperazine-1-carboxylate

benzyl 4-[(3R,3aS)-3-{[(3-nitrophenylsulfonyl)oxy]methyl}-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-7-yl]piperazine-1-carboxylate

benzyl 4-[(3S,3aS)-3-(acetamidomethyl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-7-yl]piperazine-1-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1341209-18-4 benzyl 4-(4-{[(benzyloxy)carbonyl]amino}-3-{[(2R,3S)-3-{[(tert-butyldimethylsilyl)oxy]methyl}oxiran-2-yl]methoxy}phenyl)piperazine-1-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send