(S)-1-((2-chloro-6-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)propan-2-ol

Base Information

Chemical Name:(S)-1-((2-chloro-6-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)propan-2-ol
CAS No.:1188271-31-9
Molecular Formula:C₁₈H₂₀ClN₅O₂
Molecular Weight:373.842
Hs Code.:

Synonyms:(S)-1-((2-chloro-6-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)propan-2-ol

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Chemical Property of (S)-1-((2-chloro-6-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)propan-2-ol

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Technology Process of (S)-1-((2-chloro-6-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)propan-2-ol

There total 6 articles about (S)-1-((2-chloro-6-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1188271-30-8
(S)-2-(2-chloro-6-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1188271-31-9
(S)-1-((2-chloro-6-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)propan-2-ol

Guidance literature:: (S)-2-(2-chloro-6-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone; N,N-dimethyl-formamide dimethyl acetal; at 90 ℃; for 20h;

With hydrazine hydrate; In ethanol; at 20 ℃; for 12h;

Reference yield: 41.0%

: 1188271-30-8
(S)-2-(2-chloro-6-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone

: 1188271-31-9
(S)-1-((2-chloro-6-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)propan-2-ol

Guidance literature:: (S)-2-(2-chloro-6-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone; With N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; at 90 ℃; for 12h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 585-81-9
3-hydroxy-5-methylbenzoic acid

: 1188271-31-9
(S)-1-((2-chloro-6-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dmap / acetone / 12 h / 65 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 24 h / 20 °C

3.1: tetrahydrofuran / 3 h / Reflux

4.1: 20 h / 90 °C

4.2: 12 h / 20 °C

With potassium carbonate; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; acetone;