2-(2-Benzyloxy-1-hexadecyloxymethyl-ethyl)-malonic acid diethyl ester

Base Information

• Chemical Name: 2-(2-Benzyloxy-1-hexadecyloxymethyl-ethyl)-malonic acid diethyl ester
• CAS No.: 153154-37-1
• Molecular Formula: C₃₃H₅₆O₆
• Molecular Weight: 548.804
• Mol file: 153154-37-1.mol

Synonyms:2-(2-Benzyloxy-1-hexadecyloxymethyl-ethyl)-malonic acid diethyl ester

Chemical Property of 2-(2-Benzyloxy-1-hexadecyloxymethyl-ethyl)-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(2-Benzyloxy-1-hexadecyloxymethyl-ethyl)-malonic acid diethyl ester

There total 6 articles about 2-(2-Benzyloxy-1-hexadecyloxymethyl-ethyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(hexadecyloxy)-1,2-propanediol (6145-69-3) → 2-(2-Benzyloxy-1-hexadecyloxymethyl-ethyl)-malonic acid diethyl ester (153154-37-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 45percent HBr / from 0 deg C up to room temp. in 20 min

2: phenylmethanol

3: pyridine / CH₂Cl₂

4: 1.) NaH / 1.) THF, 2.) THF

With pyridine; hydrogen bromide; sodium hydride; In dichloromethane; benzyl alcohol;

DOI:10.1016/0040-4039(93)85070-D

Reference yield:

methanesulfonic acid hexadecyl ester (20779-14-0) → 2-(2-Benzyloxy-1-hexadecyloxymethyl-ethyl)-malonic acid diethyl ester (153154-37-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMSO, room temperature, 0.5 h, 2) DMSO, 16 h

2: 100 percent / 1M HCl / methanol / 1 h / Heating

3: 45percent HBr / from 0 deg C up to room temp. in 20 min

4: phenylmethanol

5: pyridine / CH₂Cl₂

6: 1.) NaH / 1.) THF, 2.) THF

With pyridine; hydrogenchloride; hydrogen bromide; sodium hydride; In methanol; dichloromethane; benzyl alcohol;

DOI:10.1016/0040-4039(93)85070-D

Reference yield:

rac-1-O-hexadecyl-3-O-benzylglycerol (103475-80-5) → 2-(2-Benzyloxy-1-hexadecyloxymethyl-ethyl)-malonic acid diethyl ester (153154-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂

2: 1.) NaH / 1.) THF, 2.) THF

With pyridine; sodium hydride; In dichloromethane;

DOI:10.1016/0040-4039(93)85070-D

upstream raw materials:

Trifluoro-methanesulfonic acid 2-benzyloxy-1-hexadecyloxymethyl-ethyl ester

diethyl malonate

3-(hexadecyloxy)-1,2-propanediol

methanesulfonic acid hexadecyl ester

Downstream raw materials:

4-Benzyloxy-3-hexadecyloxymethyl-butyric acid hexadecyl ester

4-Benzyloxy-3-hexadecyloxymethyl-butyric acid ethyl ester