103475-80-5Relevant academic research and scientific papers
Synthesis of novel lipophilic tetraamines with cytotoxic activity
Perevoshchikova, Ksenia A.,Nichugovskiy, Artemiy I.,Isagulieva, Alexandra K.,Morozova, Nina G.,Ivanov, Igor V.,Maslov, Mikhail A.,Shtil, Alexander A.
, p. 616 - 618 (2019)
New lipophilic polyamines in which natural or synthetic tetraamines were linked via the terminal NH2 groups to diglycerides and/or to short-chained aliphatic substituents were synthesized, and their cytotoxic activity was tested. Relationship between the structure of the synthesized compounds and their cytotoxicity and hemolytic effect was evaluated.
F-18 labeling of ether-linked analogs of diacylglycerol
Hatano, Kentaro,Ito, Kengo,Ido, Tatsuo
, p. 245 - 253 (2007/10/03)
Ether-linked analogs of fluorine-18 labeled diacylglycerol were synthesized in order to improve their bioavailability in vivo. Compounds were designed to have long chain (having sixteen carbons) alkyl substituent on 1-O-position and short alkyl or acyl group (eight carbons) on 2-O-position of glycerol. Introduction of 18F into each chain resulted in four labeled tracers. Precursors having tosyloxy or bromo moiety as leaving group were obtained step wise alkylations and/or acylations of 3-O-benzylglycerol. Nucleophilic radiofluorination of the precursors thus obtained gave labeled intermediates in up to 40% radiochemical yield. Ether-linked diacylglycerol analogs were afforded through their deprotection with H2 and Pd/C. Catalytic transfer hydrogenation was also attempted, however, insufficient result was achieved in spite of its usefulness as labeling procedure.
Synthesis of novel cationic lipids with oxyethylene spacers at the linkages between hydrocarbon chains and pseudoglyceryl backbone
Bhattacharya, Santanu,Dileep
, p. 8167 - 8171 (2007/10/03)
Four novel cationic lipids with oligo-oxyethylene units at various linkage regions between the pseudoglyceryl backbone and the hydrocarbon chains have been synthesized. The membrane-forming properties of these new lipids are briefly presented.
Synthesis of a 'reverse ester' analogue of 1,2-sn-diglycerides from (S)-1,2-di-O-isoprophylideneglycerol; efficient, stereospecific nucleophilic displacement via a triflate at glycerol C-2
Golding, Bernard T.,Griffin, Alice L.,Robinson, David H.
, p. 6459 - 6462 (2007/10/02)
An optically pure glyceride analogue in which the 2-O-ester grouping has been reversed was efficiently synthesised from (S)-di-O-isopropylideneglycerol by a sequence that featured an SN 2 displacement by the anion of diethyl malonate on a protected glycerol 2-O-triflate.
