3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate

Base Information

• Chemical Name: 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate
• CAS No.: 1367717-84-7
• Molecular Formula: C₂HF₃O₂*C₂₀H₂₂N₄O₃
• Molecular Weight: 480.444
• Mol file: 1367717-84-7.mol

Synonyms:3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate

Chemical Property of 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate

There total 4 articles about 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(tert-butyl)-1H-imidazole-4-carbaldehyde (714273-83-3) → 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate (1367717-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

2.2: Inert atmosphere

With caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm2009088

Reference yield:

5-(tert-butyl)oxazole-4-carboxylic acid ethyl ester (714273-89-9) → 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate (1367717-84-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 14 h / 165 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3.1: manganese(IV) oxide / acetone / 2 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

5.2: Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm2009088

Reference yield:

5-(tert-butyl)-1H-imidazole-4-carboxylic acid ethyl ester (51721-21-2) → 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate (1367717-84-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2.1: manganese(IV) oxide / acetone / 2 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

4.2: Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm2009088

upstream raw materials:

5-(tert-butyl)oxazole-4-carboxylic acid ethyl ester

5-(tert-butyl)-1H-imidazole-4-carboxylic acid ethyl ester

5-(tert-butyl)-1H-imidazole-4-carbaldehyde

2,2-dimethylpropanoic anhydride

Refernces