N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

Base Information

• Chemical Name: N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine
• CAS No.: 1578244-08-2
• Molecular Formula: C₂₄H₂₉N₇O
• Molecular Weight: 431.541

Synonyms:N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

Chemical Property of N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

There total 14 articles about N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)formamide (1578246-27-1) + 6-methyl-2-(methylsulfonyl)-N-neopentylpyrido[3,4-d]pyrimidin-8-amine (1578246-25-9) → N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (1578244-08-2)

Guidance literature:

N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)formamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.166667h;

6-methyl-2-(methylsulfonyl)-N-neopentylpyrido[3,4-d]pyrimidin-8-amine; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 5h;

Reference yield:

5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid (50593-92-5) → N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (1578244-08-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sulfuric acid / 24 h / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 110 °C

3.1: ammonia / methanol / 18 h / 120 °C

4.1: toluene-4-sulfonic acid / toluene / 18 h / 90 °C

4.2: 18 h / 80 °C

5.1: trichlorophosphate / 1 h / 70 °C

6.1: 1-methyl-pyrrolidin-2-one / 3 h / 80 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 - 20 °C

8.2: 5 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ammonia; sodium hydride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

6-methyl-2-(methylthio)pyrido[3,4-d]pyrimidin-8(7H)-one (1578246-22-6) → N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (1578244-08-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trichlorophosphate / 1 h / 70 °C

2.1: 1-methyl-pyrrolidin-2-one / 3 h / 80 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 - 20 °C

4.2: 5 h / 0 - 20 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; mineral oil;

upstream raw materials:

5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid

methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate

methyl (2-(methylthio)-5-prop-1-yn-1-yl)pyrimidine-4-carboxylate

2-(methylthio)-5-(prop-1-yn-1-yl)pyrimidine-4-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1578244-08-2 N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send