(2R,6S,4E)-6-Benzyloxymethyloxy-1-(tert-butyldiphenylsiloxy)-2,5-dimethyl-4-octene

Base Information

Chemical Name:(2R,6S,4E)-6-Benzyloxymethyloxy-1-(tert-butyldiphenylsiloxy)-2,5-dimethyl-4-octene
CAS No.:350246-36-5
Molecular Formula:C₃₄H₄₆O₃Si
Molecular Weight:530.823
Hs Code.:

Synonyms:(2R,6S,4E)-6-Benzyloxymethyloxy-1-(tert-butyldiphenylsiloxy)-2,5-dimethyl-4-octene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,6S,4E)-6-Benzyloxymethyloxy-1-(tert-butyldiphenylsiloxy)-2,5-dimethyl-4-octene

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Technology Process of (2R,6S,4E)-6-Benzyloxymethyloxy-1-(tert-butyldiphenylsiloxy)-2,5-dimethyl-4-octene

There total 6 articles about (2R,6S,4E)-6-Benzyloxymethyloxy-1-(tert-butyldiphenylsiloxy)-2,5-dimethyl-4-octene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 3587-60-8
Benzyloxymethyl chloride

: 350246-35-4
(2R,6S,4E)-1-(tert-Butyldiphenylsiloxy)-2,5-dimethyl-4-octen-6-ol

: 350246-36-5
(2R,6S,4E)-6-Benzyloxymethyloxy-1-(tert-butyldiphenylsiloxy)-2,5-dimethyl-4-octene

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In toluene; for 14h; Heating;
DOI:10.1002/1521-3765(20010504)7:9<1845::AID-CHEM1845>3.0.CO;2-2

Reference yield:

: 815-52-1
2-bromopentan-3-one

: 350246-36-5
(2R,6S,4E)-6-Benzyloxymethyloxy-1-(tert-butyldiphenylsiloxy)-2,5-dimethyl-4-octene

Guidance literature:: Multi-step reaction with 5 steps

1: 47 percent / benzene

2: 83 percent / aq. NaOH

3: 85 percent / toluene / 6 h / 90 °C

4: 73 percent / catecholborane / (R)-CBS catalyst / toluene; CH₂Cl₂ / 24 h / -40 °C

5: 97 percent / Huenigs base; Bu₄NI / toluene / 14 h / Heating

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; benzo[1,3,2]dioxaborole; (R)-CBS catalyst; In dichloromethane; toluene; benzene; 3: Wittig olefination;
DOI:10.1002/1521-3765(20010504)7:9<1845::AID-CHEM1845>3.0.CO;2-2

Reference yield:

: 111114-35-3
triphenyl-(1-propionylethylidene)phosphorane

: 350246-36-5
(2R,6S,4E)-6-Benzyloxymethyloxy-1-(tert-butyldiphenylsiloxy)-2,5-dimethyl-4-octene

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / toluene / 6 h / 90 °C

2: 73 percent / catecholborane / (R)-CBS catalyst / toluene; CH₂Cl₂ / 24 h / -40 °C

3: 97 percent / Huenigs base; Bu₄NI / toluene / 14 h / Heating

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; benzo[1,3,2]dioxaborole; (R)-CBS catalyst; In dichloromethane; toluene; 1: Wittig olefination;
DOI:10.1002/1521-3765(20010504)7:9<1845::AID-CHEM1845>3.0.CO;2-2