4,5-Dihydro-2-<(2-nitrophenyl)amino>-4-oxo-3-furancarboxylic acid ethyl ester

Base Information

• Chemical Name: 4,5-Dihydro-2-<(2-nitrophenyl)amino>-4-oxo-3-furancarboxylic acid ethyl ester
• CAS No.: 152645-34-6
• Molecular Formula: C₁₃H₁₂N₂O₆
• Molecular Weight: 292.248

Synonyms:4,5-Dihydro-2-<(2-nitrophenyl)amino>-4-oxo-3-furancarboxylic acid ethyl ester

Chemical Property of 4,5-Dihydro-2-<(2-nitrophenyl)amino>-4-oxo-3-furancarboxylic acid ethyl ester

Chemical Property:

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Technology Process of 4,5-Dihydro-2-<(2-nitrophenyl)amino>-4-oxo-3-furancarboxylic acid ethyl ester

There total 1 articles about 4,5-Dihydro-2-<(2-nitrophenyl)amino>-4-oxo-3-furancarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl (2-chloroaceto)acetate (638-07-3) + 2-nitrophenyl isocyanate (3320-86-3) → 4,5-Dihydro-2-<(2-nitrophenyl)amino>-4-oxo-3-furancarboxylic acid ethyl ester (152645-34-6)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/jo00074a059

Reference yield: 86.0%

4,5-Dihydro-2-<(2-nitrophenyl)amino>-4-oxo-3-furancarboxylic acid ethyl ester (152645-34-6) + methyl iodide (74-88-4) → 4,5-Dihydro-2-<(2-nitrophenyl)methylamino>-4-oxo-3-furancarboxylic acid ethyl ester (152645-39-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 70 ℃; for 0.25h;

DOI:10.1021/jo00074a059

Reference yield: 7.0%

4,5-Dihydro-2-<(2-nitrophenyl)amino>-4-oxo-3-furancarboxylic acid ethyl ester (152645-34-6) → 2-(1,3-Dihydro-2H-benzimidazol-2-ylidene)-4-hydroxy-3-oxobutanoic acid ethyl ester (152645-45-9) + 2-<(2-Aminophenyl)amino>-4,5-dihydro-4-oxo-3-furancarboxylic acid ethyl ester (152645-40-4)

Guidance literature:

With cyclohexene; palladium on activated charcoal; In ethanol; Heating;

DOI:10.1021/jo00074a059

upstream raw materials:

ethyl (2-chloroaceto)acetate

2-nitrophenyl isocyanate

Downstream raw materials:

2-(1,3-Dihydro-2H-benzimidazol-2-ylidene)-4-hydroxy-3-oxobutanoic acid ethyl ester

2-<(2-Aminophenyl)amino>-4,5-dihydro-4-oxo-3-furancarboxylic acid ethyl ester

4,5-Dihydro-2-<(2-nitrophenyl)methylamino>-4-oxo-3-furancarboxylic acid ethyl ester

N-methyl-1,2-phenylenediamine

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