2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester
CAS No.:894357-60-9
Molecular Formula:C₄₇H₆₆O₅
Molecular Weight:711.038
Hs Code.:

2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester

Synonyms:2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester

There total 6 articles about 2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 894357-64-3
(25R)-5α-cholestane-3β,26-diol 26-pivalate

: 26077-80-5
(4-benzoylphenyl)acetic acid

: 894357-60-9
2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 1h;
DOI:10.1021/ol060079y

Reference yield:

: 2,2-Dimethyl-propionic acid (3S,8S,9S,10R,13S,14S,16S,17R)-17-[(1R,5R)-6-(2,2-dimethyl-propionyloxy)-1,5-dimethyl-hexyl]-16-methanesulfonyloxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

: 894357-60-9
2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / diethyl ether / 16 h / Heating

2: 99 percent / hydrogen / Pd / methanol; CH₂Cl₂ / 4 h

3: 80 percent / sodium hydride / tetrahydrofuran / 12 h / 20 °C

4: 87 percent / triphenylphosphine; DEAD / tetrahydrofuran / 1 h / 25 °C

With lithium aluminium tetrahydride; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; palladium; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 4: Mitsunobu reaction;
DOI:10.1021/ol060079y

Reference yield:

: 894357-63-2
(25R)-cholest-5-ene-3β,16β,26-triol 3β,26-dipivalate

: 894357-60-9
2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 0 - 20 °C

2: LiAlH₄ / diethyl ether / 16 h / Heating

3: 99 percent / hydrogen / Pd / methanol; CH₂Cl₂ / 4 h

4: 80 percent / sodium hydride / tetrahydrofuran / 12 h / 20 °C

5: 87 percent / triphenylphosphine; DEAD / tetrahydrofuran / 1 h / 25 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; palladium; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 5: Mitsunobu reaction;
DOI:10.1021/ol060079y