26077-80-5Relevant articles and documents
A reversible and selective inhibitor of monoacylglycerol lipase ameliorates multiple sclerosis
Hernndez-Torres, Gloria,Cipriano, Mariateresa,Hedn, Erika,Bj?rklund, Emmelie,Canales, Angeles,Zian, Debora,Feli, Ana,Mecha, Miriam,Guaza, Carmen,Fowler, Christopher J.,Ortega-Gutirrez, Silvia,Lpez-Rodrguez, Maria L.
, p. 13765 - 13770 (2015/01/16)
Monoacylglycerol lipase (MAGL) is the enzyme responsible for the inactivation of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibitors show analgesic and tissue-protecting effects in several disease models. However, the few efficient and selective MAGL inhibitors described to date block the enzyme irreversibly, and this can lead to pharmacological tolerance. Hence, additional classes of MAGL inhibitors are needed to validate this enzyme as a therapeutic target. Here we report a potent, selective, and reversible MAGL inhibitor (IC50 = 0.18 mm) which is active in vivo and ameliorates the clinical progression of a multiple sclerosis (MS) mouse model without inducing undesirable CB1-mediated side effects. These results support the interest in MAGL as a target for the treatment of MS.
Photochemistry of benzophenone immobilized in a major groove of DNA: Formation of thermally reversible interstrand cross-link
Nakatani, Kazuhiko,Yoshida, Takashi,Saito, Isao
, p. 2118 - 2119 (2007/10/03)
We here report a highly site and sequence selective formation of an interstrand cross-link of BPU-containing oligomer duplexes. The cross-link was found spontaneously reverted to original oligomers upon heating, providing a new method for the temporary connection of two DNA strands. Copyright
Efficient photodecarboxylation of aroyl-substituted phenylacetic acids in aqueous solution: A general photochemical reaction
Xu,Wan
, p. 2147 - 2148 (2007/10/03)
Photolysis (254-350 nm) of a variety of aroyl-substituted phenylacetic acids and p-acetylphenylacetic acid in aqueous solution at pH > pK(a) resulted in efficient photodecarboxylation (Φ = 0.2-0.7), to give in most cases a single product arising via the corresponding arylmethyl carbanion, indicating that photodecarboxylation is an efficient and general reaction for these types of compounds.