2-(4'-(diphenylamino)biphenyl-4-yl)thiazole-5-carbaldehyde

Base Information

• Chemical Name: 2-(4'-(diphenylamino)biphenyl-4-yl)thiazole-5-carbaldehyde
• CAS No.: 1352915-41-3
• Molecular Formula: C₂₈H₂₀N₂OS
• Molecular Weight: 432.546
• Mol file: 1352915-41-3.mol

Synonyms:2-(4'-(diphenylamino)biphenyl-4-yl)thiazole-5-carbaldehyde

Chemical Property of 2-(4'-(diphenylamino)biphenyl-4-yl)thiazole-5-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4'-(diphenylamino)biphenyl-4-yl)thiazole-5-carbaldehyde

There total 2 articles about 2-(4'-(diphenylamino)biphenyl-4-yl)thiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

C27H20N2S (1352915-42-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(4'-(diphenylamino)biphenyl-4-yl)thiazole-5-carbaldehyde (1352915-41-3)

Guidance literature:

C₂₇H₂₀N₂S; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -35 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tet.2011.10.038

Reference yield:

(4’-(diphenylamino)-[ 1,1‘-biphenyl]-4-yl)boronic acid (668493-36-5) → 2-(4'-(diphenylamino)biphenyl-4-yl)thiazole-5-carbaldehyde (1352915-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 24 h / 85 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

2.2: 1.5 h / -35 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; In tetrahydrofuran; ethanol; hexane; water; toluene; 1.1: Suzuki coupling;

DOI:10.1016/j.tet.2011.10.038

Reference yield: 90.0%

2-(4'-(diphenylamino)biphenyl-4-yl)thiazole-5-carbaldehyde (1352915-41-3) + cyanoacetic acid (372-09-8) → C31H21N3O2S

Guidance literature:

With piperidine; In acetonitrile; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2011.10.038

upstream raw materials:

C₂₇H₂₀N₂S

N,N-dimethyl-formamide

(4’-(diphenylamino)-[ 1,1‘-biphenyl]-4-yl)boronic acid