cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Base Information

Chemical Name:cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid
CAS No.:1415571-54-8
Molecular Formula:C₂₄H₂₇ClN₄O₃
Molecular Weight:454.956
Hs Code.:

Synonyms:cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Suppliers and Price of cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

There total 7 articles about cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1415571-53-7
cis-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

: 1415571-54-8
cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 40 ℃;
DOI:10.1021/ml5003426

Reference yield:

: 677728-92-6
2-fluoro-5-formylpyridine

: 1415571-54-8
cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Oxone / N,N-dimethyl acetamide; water / 0 - 20 °C

2: sodium hydrogencarbonate / dimethyl sulfoxide / 110 °C / Inert atmosphere

3: lithium hydroxide / tetrahydrofuran; water; methanol / 40 °C

With Oxone; sodium hydrogencarbonate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; dimethyl sulfoxide;
DOI:10.1021/ml5003426

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1415571-54-8
cis-4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 20 - 55 °C / Inert atmosphere

2: platinum(IV) oxide; toluene-4-sulfonic acid; hydrogen / ethanol / 40 h / 20 °C / 2327.23 Torr / Inert atmosphere

3: sodium hydrogencarbonate / dimethyl sulfoxide / 110 °C / Inert atmosphere

4: lithium hydroxide / tetrahydrofuran; water; methanol / 40 °C

With platinum(IV) oxide; di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/ml5003426